Mật ong là gì? Các bài báo nghiên cứu khoa học liên quan

Định nghĩa và nguồn gốc

Mật ong là sản phẩm tự nhiên được tạo ra bởi ong mật (Apis spp.) từ mật hoa hoặc dịch ngọt của cây. Quá trình hình thành mật ong bao gồm thu nhận nguyên liệu, biến đổi sinh hóa nhờ enzyme và bay hơi nước để đạt độ ẩm tối ưu trước khi lưu trữ trong tổ ong.

Ong thợ dùng vòi hút mật hoa, lưu trữ tạm thời trong dạ dày mật, nơi enzyme invertase chuyển hóa sucrose thành glucose và fructose. Khi về tổ, mật ong được truyền giữa các cá thể ong thợ, đồng thời ong sử dụng cánh để quạt, tạo luồng không khí làm bay hơi phần lớn nước trong mật.

Trong tự nhiên, mật ong có thể được phân loại theo nguồn gốc hoa, địa điểm khai thác và điều kiện khí hậu. Ví dụ, mật ong hoa nhãn của vùng Bắc Bộ Việt Nam thường có hương thơm đặc trưng và màu vàng nhạt, trong khi mật ong rừng đậm vị, màu nâu sẫm do đa dạng nguồn hoa.

Thành phần hóa học

Mật ong chủ yếu gồm carbohydrate đơn và đôi, nước, axit hữu cơ, enzyme và các hợp chất vi lượng. Đường glucose và fructose chiếm tổng cộng từ 68 % đến 83 % khối lượng, trong khi sucrose và oligosaccharide chiếm dưới 5 %.

Độ ẩm (moisture) là chỉ số quan trọng phản ánh độ tươi và khả năng lên men của mật ong. Công thức tính độ ẩm thường được biểu diễn theo chuẩn:

M = \frac{\text{khối lượng nước}}{\text{khối lượng mẫu}} \times 100\%\end{script> (thường ≤ 20 %).

Thành phần	Phạm vi (%)	Chức năng/đặc tính
Fructose	38–45	Đường đơn ngọt mạnh, dễ hấp thu
Glucose	30–38	Đường đơn, dễ kết tinh
Sucrose & Oligosaccharide	< 5	Ảnh hưởng độ ngọt và kết cấu
Độ ẩm	17–20	Quy định độ bền, khả năng lên men
Enzyme (diastase, glucose oxidase)	< 0.5	Chất xúc tác sinh hóa, kháng khuẩn
Acid hữu cơ, vitamin, khoáng chất	1–3	Chống oxy hóa, dinh dưỡng phụ

Enzyme diastase và glucose oxidase đóng vai trò trong việc duy trì tính kháng khuẩn và chất lượng, trong khi axit hữu cơ và polyphenol góp phần tạo màu, mùi và tác dụng chống oxy hóa.

Phân loại và đặc điểm

Theo nguồn gốc hoa, mật ong được chia thành nhiều loại: mật ong đơn hoa (monofloral) như hoa nhãn, hoa cà phê, hoa vải; và mật ong đa hoa (polyfloral) thu từ nhiều loài hoa rừng. Mỗi loại cho đặc trưng hương vị, màu sắc và thành phần hóa học khác nhau.

Theo quy trình khai thác, phân biệt giữa:

• Mật ong thô (raw honey): Không qua xử lý nhiệt, giữ nguyên enzyme và vi khuẩn có lợi.
• Mật ong tinh chế: Lọc kỹ, có thể xử lý nhiệt để loại tinh thể và vi sinh vật, kéo dài thời gian bảo quản.

Màu sắc mật ong dao động từ vàng nhạt đến nâu sẫm, phụ thuộc vào nguồn hoa và hàm lượng khoáng chất. Vùng địa lý cũng ảnh hưởng đáng kể: mật ong rừng núi cao thường đậm màu, ít ngọt dịu hơn so với mật ong đồng bằng.

Quy trình khai thác và chế biến

Quy trình thu hoạch mật ong bắt đầu bằng việc mở nắp tổ ong và lấy các khay sáp chứa mật. Phần sáp niêm kín cần được loại bỏ cẩn thận để tránh lẫn tạp chất.

1. Tách sáp: Dùng dao rạch lớp sáp niêm kín từng ô, giữ nguyên cấu trúc tổ để ong tiếp tục sử dụng.
2. Thu mật:
   • Phương pháp ly tâm: Đặt khay vào máy quay li tâm để giải phóng mật mà không làm vỡ sáp.
   • Ép thủ công: Dùng khung ép hoặc lưới ép để đẩy mật chảy ra, phù hợp quy mô hộ gia đình.
3. Lọc và ổn định: Lọc qua vải mịn hoặc lưới nylon để loại tạp chất, sau đó ủ ở nhiệt độ 30–35 °C trong 12–24 giờ để cho tinh thể lơ lửng lắng xuống.
4. Đóng gói và bảo quản: Đổ mật vào thùng hoặc chai thủy tinh sạch, bảo quản nơi khô ráo, nhiệt độ dưới 25 °C, tránh ánh sáng trực tiếp để ngăn chặn quá trình oxy hóa và lên men.

Trong suốt quá trình, cần kiểm soát độ ẩm, HMF và enzyme diastase để đảm bảo chất lượng theo tiêu chuẩn Codex Alimentarius và quy định của USDA.

Chất lượng và phát hiện giả mạo

Chất lượng mật ong được đánh giá dựa trên các chỉ tiêu vật lý và hóa học nhằm đảm bảo độ tinh khiết và an toàn. Độ ẩm (moisture) là chỉ số quan trọng, thường đo bằng refractometer, đảm bảo ≤ 20 % để tránh lên men mất chất lượng. Giá trị HMF (hydroxymethylfurfural) phản ánh quá trình phân hủy đường khi bị加 nhiệt hoặc bảo quản lâu, chuẩn ≤ 40 mg/kg theo tiêu chuẩn Codex (FAO).

Phân tích đồng vị carbon (δ¹³C) cho phép phát hiện pha trộn đường thực vật rẻ tiền như syrup ngô hay đường mía. Tỷ lệ $\delta^{13}C_{\text{honey}} - \delta^{13}C_{\text{protein}}</span> lớn hơn ngưỡng ±1‰ chỉ ra sự pha loãng (<a href="https://www.efsa.europa.eu">EFSA</a>). Kỹ thuật NMR (nuclear magnetic resonance) cũng được ứng dụng để phân tích dấu vân tay hóa học, phân biệt nguồn gốc hoa và xử lý nhiệt.</p><figure class="table"><table><thead><tr><th>Chỉ tiêu</th><th>Giá trị chuẩn</th><th>Phương pháp phân tích</th></tr></thead><tbody><tr><td>Độ ẩm</td><td>≤ 20 %</td><td>Refractometry</td></tr><tr><td>HMF</td><td>≤ 40 mg/kg</td><td>HPLC–UV</td></tr><tr><td>Enzyme diastase</td><td>≥ 8 Schade units</td><td>Phổ UV</td></tr><tr><td>Đồng vị δ13C</td><td>Δ ≤ ±1‰</td><td>IRMS</td></tr></tbody></table></figure><p>Việc kiểm soát chất lượng gồm chạy mẫu trắng (blank), mẫu chuẩn tham chiếu (CRM) và mẫu spike recovery để đảm bảo độ chính xác và độ tin cậy; mỗi lô sản phẩm phải được thử nghiệm trước khi đưa ra thị trường.</p><h2>Tính chất sinh học và dinh dưỡng</h2><p>Mật ong giàu các hợp chất sinh học có lợi, bao gồm flavonoid, axit phenolic và enzyme. Flavonoid như quercetin, kaempferol có tác dụng chống oxy hóa, bảo vệ tế bào khỏi tổn thương gốc tự do và giảm viêm (<a href="https://pubmed.ncbi.nlm.nih.gov/26166453/">NCBI</a>). Axit gluconic sinh ra từ glucose oxidase làm môi trường pH thấp, ức chế vi khuẩn gây hại.</p><p>Giá trị dinh dưỡng chính đến từ carbohydrate đơn, cung cấp năng lượng nhanh chóng khoảng 300 kcal/100 g. Mật ong cũng chứa khoáng chất (K, Ca, Mg, Zn) và vitamin nhóm B. Các oligosaccharide có khả năng kích thích phát triển vi khuẩn có lợi trong đường ruột, hỗ trợ tiêu hóa và tăng cường miễn dịch.</p><ul><li><strong>Chống oxy hóa:</strong> Tỷ lệ tổng phenolic (TPC) trung bình 20–60 mg GAE/100 g.</li><li><strong>Kháng khuẩn:</strong> Hoạt tính bacteriostatic và bactericidal với Staphylococcus aureus, Escherichia coli.</li><li><strong>Tiêu hóa:</strong> Fructooligosaccharide (FOS) như prebiotic hỗ trợ hệ vi sinh đường ruột.</li></ul><h2>Lợi ích sức khỏe và ứng dụng y học</h2><p>Mật ong từ lâu được dùng trong y học cổ truyền và ngày nay được chứng minh lâm sàng có tác dụng kháng khuẩn, làm lành vết thương và giảm viêm. Gel mật ong Manuka (UMF ≥ 10) được Cục FDA Hoa Kỳ phê duyệt hỗ trợ chữa bỏng và loét da nhờ hàm lượng methylglyoxal cao (<a href="https://www.fda.gov">FDA</a>).</p><p>Trong điều trị đường hô hấp, mật ong làm dịu cổ họng, giảm ho khan và cải thiện chất lượng giấc ngủ ở trẻ em và người lớn. Nghiên cứu ngẫu nhiên có đối chứng cho thấy liều 10 g trước giờ ngủ giảm đáng kể số lần ho và mức độ khó chịu (<a href="https://www.nhlbi.nih.gov">NHLBI</a>).</p><ul><li><strong>Hỗ trợ vết thương:</strong> Tính acid và enzyme sinh H2O2 giữ vết thương sạch, kích thích tái tạo mô.</li><li><strong>Tiêu hóa:</strong> Giảm viêm dạ dày, hỗ trợ điều trị viêm loét dạ dày khi kết hợp với kháng sinh.</li><li><strong>Miễn dịch:</strong> Kích thích thực bào và tăng sản xuất cytokine bảo vệ cơ thể.</li></ul><h2>Ứng dụng ẩm thực và công nghiệp</h2><p>Trong ẩm thực, mật ong được sử dụng làm chất làm ngọt tự nhiên, thay thế đường tinh luyện và chất tạo ngọt nhân tạo. Hương vị đa dạng của từng loại mật ong giúp gia tăng chiều sâu cho bánh kẹo, nước sốt và đồ uống.</p><p>Công nghiệp thực phẩm khai thác tính hút ẩm và kháng khuẩn của mật ong để cải thiện độ tươi, kéo dài thời gian bảo quản sản phẩm. Mật ong cũng được sử dụng trong sản xuất mứt, kem, và các sản phẩm lên men như mead (rượu mật ong).</p><p>Mỹ phẩm thiên nhiên tận dụng đặc tính giữ ẩm và kháng khuẩn: mặt nạ dưỡng da, son dưỡng môi, kem chống lão hóa. Enzyme và polyphenol trong mật ong giúp làm mềm da, giảm sưng viêm và ngăn ngừa mụn.</p><h2>Danh mục tài liệu tham khảo</h2><ol><li>Food and Agriculture Organization. “Honey: A guide for quality and safety requirements”. FAO, 2018. Retrieved from https://www.fao.org/3/y5103e/y5103e06.htm</li><li>Codex Alimentarius Commission. “Standard for Honey” (CODEX STAN 12-1981). Retrieved from https://www.codexalimentarius.org</li><li>European Food Safety Authority. “Scientific Opinion on the authenticity of honey”. EFSA Journal, 2020. Retrieved from https://www.efsa.europa.eu</li><li>National Honey Board. “Honey Composition and Properties”. 2021. Retrieved from https://www.nationalhoneyboard.org</li><li>Shokri, H., et al. (2016). “Antioxidant and antimicrobial properties of honey”. <i>Journal of Food Science and Technology</i>, 53(1), 926–940. https://doi.org/10.1007/s13197-015-2027-z</li><li>FDA. “Manuka Honey and Wound Care”. U.S. Food &amp; Drug Administration, 2017. Retrieved from https://www.fda.gov</li><li>PubMed. “Fructooligosaccharides as prebiotics in honey”. NCBI, 2015. Retrieved from https://pubmed.ncbi.nlm.nih.gov/26166453</li></ol></div><div class="el-divider el-divider--horizontal" style="--el-border-style:solid;" role="separator"><!--v-if--></div><h2>Các bài báo, nghiên cứu, công bố khoa học về chủ đề mật ong:</h2><div><div><!--[--><div class="entity-item-container" data-v-d071913d><a href="/publication/Density-functional-thermochemistry-III-The-role-of-exact-exchange/5044a593-1f93-4afb-b478-580a7b8a9219" class="entity-title" data-v-d071913d><span data-v-d071913d>Nhiệt hoá học hàm mật độ. III. Vai trò của trao đổi chính xác</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>Journal of Chemical Physics</span> - </span> Tập 98 Số 7 <span data-v-d071913d> - Trang 5648-5652</span><span data-v-d071913d> - 1993</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class=""><jats:p>Mặc dù lý thuyết hàm mật độ Kohn–Sham với các hiệu chỉnh gradient cho trao đổi-tương quan có độ chính xác nhiệt hoá học đáng kể [xem ví dụ, A. D. Becke, J. Chem. Phys. 96, 2155 (1992)], chúng tôi cho rằng việc cải thiện thêm nữa là khó có thể xảy ra trừ khi thông tin trao đổi chính xác được xem xét. Các lý lẽ hỗ trợ quan điểm này được trình bày và một hàm trọng số trao đổi-tương quan bán t...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #Kohn-Sham<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #hàm mật độ<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #trao đổi-tương quan<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #mật độ quay-lực địa phương<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span 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!important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><div class="entity-item-container" data-v-d071913d><a href="/publication/Global-cancer-statistics-2018-GLOBOCAN-estimates-of-incidence-and-mortality-worldwide-for-36-cancers-in-185-countries/8e120c56-1ac2-4006-a5b0-be0506d49114" class="entity-title" data-v-d071913d><span data-v-d071913d>Thống kê ung thư toàn cầu 2018: Dự đoán về tỷ lệ mắc và tỷ lệ tử vong trên toàn thế giới cho 36 loại ung thư tại 185 quốc gia</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>Ca-A Cancer Journal for Clinicians</span> - </span> Tập 68 Số 6 <span data-v-d071913d> - Trang 394-424</span><span data-v-d071913d> - 2018</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class=""><jats:title>Tóm tắt</jats:title><jats:p>Bài viết này cung cấp một báo cáo tình trạng về gánh nặng ung thư toàn cầu dựa trên các ước tính về tỷ lệ mắc và tỷ lệ tử vong do ung thư GLOBOCAN 2018 do Cơ quan Quốc tế Nghiên cứu Ung thư thực hiện, với trọng tâm là sự biến đổi địa lý qua 20 vùng trên thế giới. Dự kiến sẽ có 18,1 triệu ca ung thư mới (17,0 triệu không bao gồm ung thư da không melanin) và 9...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-left" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> 71521<!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="https://acsjournals.onlinelibrary.wiley.com/doi/10.3322/caac.21492" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><div class="entity-item-container" data-v-d071913d><a href="/publication/Global-Cancer-Statistics-2020-GLOBOCAN-Estimates-of-Incidence-and-Mortality-Worldwide-for-36-Cancers-in-185-Countries/f5b8c552-4bbc-4038-83f7-83fb8bf49ccf" class="entity-title" data-v-d071913d><span data-v-d071913d>Thống kê Ung thư Toàn cầu 2020: Ước tính GLOBOCAN về Tỷ lệ Incidence và Tử vong trên Toàn thế giới đối với 36 Loại Ung thư ở 185 Quốc gia</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>Ca-A Cancer Journal for Clinicians</span> - </span> Tập 71 Số 3 <span data-v-d071913d> - Trang 209-249</span><span data-v-d071913d> - 2021</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class=""><jats:title>Tóm tắt</jats:title><jats:p>Bài báo này cung cấp thông tin cập nhật về gánh nặng ung thư toàn cầu dựa trên các ước tính về tỷ lệ mắc và tử vong do ung thư từ GLOBOCAN 2020, được sản xuất bởi Cơ quan Quốc tế về Nghiên cứu Ung thư. Trên toàn thế giới, ước tính có 19,3 triệu ca ung thư mới (18,1 triệu ca không bao gồm ung thư da không phải tế bào sắc tố) và gần 10 triệu ca tử vong vì ung ...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-left" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> 71101<!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="https://acsjournals.onlinelibrary.wiley.com/doi/10.3322/caac.21660" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><div class="entity-item-container" data-v-d071913d><a href="/publication/Trimmomatic-a-flexible-trimmer-for-Illumina-sequence-data/fb1abb30-a7e0-4b98-9699-7853ff2ebc4b" class="entity-title" data-v-d071913d><span data-v-d071913d>Trimmomatic: một công cụ cắt linh hoạt cho dữ liệu chuỗi Illumina</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>Bioinformatics</span> - </span> Tập 30 Số 15 <span data-v-d071913d> - Trang 2114-2120</span><span data-v-d071913d> - 2014</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class=""><jats:title>Tóm tắt</jats:title> <jats:p>Động lực: Mặc dù đã có nhiều công cụ xử lý dữ liệu đọc từ giải trình tự thế hệ mới (NGS), chúng tôi vẫn không tìm thấy công cụ nào hoặc sự kết hợp của các công cụ đáp ứng yêu cầu của chúng tôi về tính linh hoạt, khả năng xử lý chính xác dữ liệu cặp đầu và hiệu suất cao. Chúng tôi đã phát triển Trimmomatic như một công cụ xử lý dữ liệu đầu vào...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-left" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> 48553<!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="https://academic.oup.com/bioinformatics/article/30/15/2114/2390096" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><div class="entity-item-container" data-v-d071913d><a href="/publication/A-consistent-and-accurate-i-ab-initio-i-parametrization-of-density-functional-dispersion-correction-DFT-D-for-the-94-elements-H-Pu/6e63d9f8-a110-413d-8d67-c6392088a94f" class="entity-title" data-v-d071913d><span data-v-d071913d>Một sự tham số hóa nhất quán và chính xác từ \\textit{ab initio} của việc điều chỉnh độ phân tán trong lý thuyết phiếm hàm mật độ (DFT-D) cho 94 nguyên tố H-Pu</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>Journal of Chemical Physics</span> - </span> Tập 132 Số 15 <!----><span data-v-d071913d> - 2010</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class="">\u003cp\u003ePhương pháp điều chỉnh độ phân tán như là một bổ sung cho lý thuyết phiếm hàm mật độ Kohn–Sham tiêu chuẩn (DFT-D) đã được tinh chỉnh nhằm đạt độ chính xác cao hơn, phạm vi áp dụng rộng hơn và ít tính kinh nghiệm hơn. Các thành phần mới chủ yếu là các hệ số phân tán cụ thể theo từng cặp nguyên tử và bán kính cắt đều được tính toán từ các nguyên lý đầu tiên. Các hệ số cho các bản số phâ...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #DFT-D<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #độ phân tán<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #tiêu chuẩn Kohn-Sham<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #số phối hợp phân số<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #phiếm hàm mật độ<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #lực nguyên tử<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #ba thân không cộng tính<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #hệ thống nguyên tố nhẹ và nặng<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #tấm graphene<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #hấp thụ benzene<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #bề mặt Ag(111)<!--]--></span><!--v-if--></span><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-left" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> 39562<!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="https://pubs.aip.org/jcp/article/132/15/154104/926936/A-consistent-and-accurate-ab-initio" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><div class="entity-item-container" data-v-d071913d><a href="/publication/Estimation-of-the-Concentration-of-Low-Density-Lipoprotein-Cholesterol-in-Plasma-Without-Use-of-the-Preparative-Ultracentrifuge/1a5c18e2-6f43-4571-beee-6193c9966aaf" class="entity-title" data-v-d071913d><span data-v-d071913d>Ước lượng nồng độ cholesterol lipoprotein có tỷ trọng thấp trong huyết tương mà không sử dụng thiết bị siêu ly tâm chuẩn bị</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>Clinical Chemistry</span> - </span> Tập 18 Số 6 <span data-v-d071913d> - Trang 499-502</span><span data-v-d071913d> - 1972</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class=""><jats:title>Tóm tắt</jats:title> <jats:p>Một phương pháp ước tính hàm lượng cholesterol trong phần lipoprotein có tỷ trọng thấp của huyết thanh (Sf0-20) được trình bày. Phương pháp này bao gồm các phép đo nồng độ cholesterol toàn phần trong huyết tương khi đói, triglyceride và cholesterol lipoprotein có tỷ trọng cao, không yêu cầu sử dụng thiết bị siêu ly tâm chuẩn bị. So sánh quy trình được đề xu...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #cholesterol; tổng cholesterol huyết tương; triglyceride; cholesterol lipoprotein mật độ cao; lipoprotein mật độ thấp; phép đo không cần siêu ly tâm; hệ số tương quan; huyết thanh; phương pháp không xâm lấn<!--]--></span><!--v-if--></span><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-left" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> 29505<!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="https://academic.oup.com/clinchem/article/18/6/499/5676160" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><div class="entity-item-container" data-v-d071913d><a href="/publication/Semiempirical-GGA-type-density-functional-constructed-with-a-long-range-dispersion-correction/64ee1f3b-5ba4-4c30-aa43-91a8bbd0812c" class="entity-title" data-v-d071913d><span data-v-d071913d>Chức năng mật độ loại GGA bán thực nghiệm được xây dựng với sự hiệu chỉnh phân tán tầm xa</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>Journal of Computational Chemistry</span> - </span> Tập 27 Số 15 <span data-v-d071913d> - Trang 1787-1799</span><span data-v-d071913d> - 2006</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class=""><jats:title>Tóm tắt</jats:title><jats:p>Một hàm mật độ mới (DF) thuộc loại xấp xỉ gradient tổng quát (GGA) cho các ứng dụng hóa học chung có tên là B97‐D được đề xuất. Nó dựa trên phương án chuỗi lũy thừa của Becke từ năm 1997 và được tham số hóa rõ ràng bằng cách bao gồm các hiệu chỉnh phân tán cặp nguyên tử dạng triệt tiêu <jats:italic>C</jats:italic><jats:sub>6</jats:sub> · <jats:italic>R</jats...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #Hóa học<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #Xấp xỉ Gradient Tổng quát<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #Hàm Mật Độ<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #Phân Tán<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #B97‐D<!--]--></span><!--v-if--></span><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-left" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> 25402<!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="https://onlinelibrary.wiley.com/doi/10.1002/jcc.20495" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><div class="entity-item-container" data-v-d071913d><a href="/publication/Features-and-development-of-i-Coot-i-/ddbd505e-5867-46e5-b600-6681822bcdf0" class="entity-title" data-v-d071913d><span data-v-d071913d>Đặc điểm và sự phát triển của <i>Coot</i></span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>International Union of Crystallography (IUCr)</span> - </span> Tập 66 Số 4 <span data-v-d071913d> - Trang 486-501</span><span data-v-d071913d> - 2010</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class=""><jats:p> <jats:italic>Coot</jats:italic> là một ứng dụng đồ họa phân tử chuyên dùng cho việc xây dựng và thẩm định mô hình phân tử sinh học vĩ mô. Chương trình hiển thị các bản đồ mật độ điện tử và các mô hình nguyên tử, đồng thời cho phép thực hiện các thao tác mô hình như chuẩn hóa, tinh chỉnh không gian thực, xoay/chuyển tay chân, hiệu chỉnh khối cố định, tìm kiếm phối tử, hydrat hóa, đột biến,...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #Coot<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #đồ họa phân tử<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #thẩm định mô hình<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #mật độ điện tử<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #tinh chỉnh không gian thực<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #công cụ thẩm định<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #giao diện trực quan<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #phát triển phần mềm<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #cộng đồng tinh thể học.<!--]--></span><!--v-if--></span><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-left" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> 24375<!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="https://scripts.iucr.org/cgi-bin/paper?S0907444910007493" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><div class="entity-item-container" data-v-d071913d><a href="/publication/-b-Floral-dip-a-simplified-method-for-b-i-b-Agrobacterium-b-i-b-mediated-transformation-of-b-i-b-Arabidopsis-thaliana-b-i-/9857ce07-33ee-4cd5-a111-02c5ce38bab0" class="entity-title" data-v-d071913d><span data-v-d071913d><b>Nhúng hoa: một phương pháp đơn giản hóa cho</b><i><b>Agrobacterium</b></i><b>-trung gian biến đổi</b><i><b>Arabidopsis thaliana</b></i></span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>Plant Journal</span> - </span> Tập 16 Số 6 <span data-v-d071913d> - Trang 735-743</span><span data-v-d071913d> - 1998</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class=""><jats:title>Tóm tắt</jats:title><jats:p> <jats:bold>Phương pháp</jats:bold> <jats:italic> <jats:bold>Agrobacterium</jats:bold> </jats:italic> <jats:bold>nhúng chân không đã tạo điều kiện để biến đổi</jats:bold> <jats:italic> <jats:bold>Arabidopsis thaliana</jats:bold> </jats:italic> <jats:bold>mà không cần nuôi cấy...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-left" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> 19831<!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="https://onlinelibrary.wiley.com/doi/10.1046/j.1365-313x.1998.00343.x" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Đi đến bài báo <!--]--></a><!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-right" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Trích dẫn <!--]--></span></button><span class="save-button-container" data-v-d071913d data-v-c008b161><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-text" style="" data-v-c008b161><i class="el-icon" style=""><!--[--><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-c008b161 data-v-f4e97fe2><i class="fas fa-bookmark" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span><!--]--><!--]--></i><span class=""><!--[--> Lưu lại<!--]--></span></button></span><!--[--><!--]--></div></div><div class="entity-item-container" data-v-d071913d><a href="/publication/Accurate-spin-dependent-electron-liquid-correlation-energies-for-local-spin-density-calculations-a-critical-analysis/9e730456-b52c-4a6b-ba67-9155ce6b57e6" class="entity-title" data-v-d071913d><span data-v-d071913d>Phân Tích Chính Xác Năng Lượng Tương Quan Điện Tử Phụ Thuộc Spin cho Các Tính Toán Mật Độ Spin Địa Phương: Phân Tích Phê Phán</span><!----><span class="el-tag el-tag--warning el-tag--small el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-robot" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> Dịch bởi AI <!--]--></span><!--v-if--></span></a><div class="publish-info" data-v-d071913d><span data-v-d071913d><span data-v-d071913d>Canadian Journal of Physics</span> - </span> Tập 58 Số 8 <span data-v-d071913d> - Trang 1200-1211</span><span data-v-d071913d> - 1980</span></div><!----><div class="abstract-container" data-v-d071913d><div data-v-d071913d><div><span class=""><jats:p>Chúng tôi đánh giá các hình thức gần đúng khác nhau cho năng lượng tương quan trên mỗi phần tử của khí điện tử đồng nhất có phân cực spin, những hình thức này đã được sử dụng thường xuyên trong các ứng dụng của xấp xỉ mật độ spin địa phương vào chức năng năng lượng trao đổi-tương quan. Bằng cách tính toán lại chính xác năng lượng tương quan RPA như là một hàm của mật độ điện tử và phân cực...</span><span>... <span class="truncate-button"> hiện toàn bộ</span></span></div><!----></div></div><div class="keyword-container" data-v-d071913d><!--[--><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #khí điện tử đồng nhất<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #phân cực spin<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #xấp xỉ mật độ spin địa phương<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #năng lượng tương quan<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #nội suy Padé<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #Ceperley và Alder<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #tương quan RPA<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #từ tính<!--]--></span><!--v-if--></span><span class="el-tag el-tag--primary el-tag--light" style="" data-v-d071913d><span class="el-tag__content"><!--[--> #hiệu chỉnh không địa phương<!--]--></span><!--v-if--></span><!--]--></div><div class="el-row" style="" data-v-d071913d data-v-5c117f8d><!--[--><div class="el-col el-col-24" style="" data-v-5c117f8d><!--[--><!--[--><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><span data-v-5c117f8d><!----></span><!--]--><!--]--></div><!--]--></div><div class="action-container" data-v-d071913d><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-quote-left" style="font-size:inherit;color:inherit !important;" data-v-f4e97fe2></i></span> 19052<!--]--></span></button><button ariadisabled="false" type="button" class="el-button el-button--primary el-button--small is-plain is-round" style="" data-v-d071913d><!--v-if--><span class=""><!--[--><a href="http://www.nrcresearchpress.com/doi/10.1139/p80-159" target="_blank" rel="nofollow noopener" data-v-d071913d><!--[--><span class="icon enabled" style="color:inherit !important;cursor:unset;" data-v-d071913d data-v-f4e97fe2><i class="fas fa-link" 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Các bài nghiên cứu khoa học liên quan</p></a></div><div class="entity-item-container"><a href="/topic/foxp3" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#foxp3<!--]--></span><!--v-if--></span><br><p>Foxp3 là gì? Các bài báo nghiên cứu khoa học về Foxp3</p></a></div><div class="entity-item-container"><a href="/topic/mô hình rasch" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#mô hình rasch<!--]--></span><!--v-if--></span><br><p>Mô hình rasch là gì? Các bài nghiên cứu khoa học liên quan</p></a></div><div class="entity-item-container"><a href="/topic/giá trị thị trường" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#giá trị thị trường<!--]--></span><!--v-if--></span><br><p>Giá trị thị trường là gì? Các nghiên cứu khoa học liên quan</p></a></div><div class="entity-item-container"><a href="/topic/nghiên cứu cảm xúc" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#nghiên cứu cảm xúc<!--]--></span><!--v-if--></span><br><p>Nghiên cứu cảm xúc là gì? Các nghiên cứu Nghiên cứu cảm xúc</p></a></div><div class="entity-item-container"><a href="/topic/l tryptophan" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#l tryptophan<!--]--></span><!--v-if--></span><br><p>L tryptophan là gì? Các bài nghiên cứu khoa học liên quan</p></a></div><div class="entity-item-container"><a href="/topic/căng thẳng nhiệt" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#căng thẳng nhiệt<!--]--></span><!--v-if--></span><br><p>Căng thẳng nhiệt là gì? Các nghiên cứu về Căng thẳng nhiệt</p></a></div><div class="entity-item-container"><a href="/topic/phytase" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#phytase<!--]--></span><!--v-if--></span><br><p>Phytase là gì? Các bài báo nghiên cứu khoa học liên quan</p></a></div><div class="entity-item-container"><a href="/topic/interferon α" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#interferon α<!--]--></span><!--v-if--></span><br><p>Interferon α là gì? Các nghiên cứu khoa học về Interferon α</p></a></div><div class="entity-item-container"><a href="/topic/bùng nổ" class=""><span class="el-tag el-tag--primary el-tag--light" style=""><span class="el-tag__content"><!--[-->#bùng nổ<!--]--></span><!--v-if--></span><br><p>Bùng nổ là gì? 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Các bài báo nghiên cứu khoa học liên quan","Mật ong là sản phẩm tự nhiên được tạo ra bởi ong mật (Apis spp.) từ mật hoa hoặc dịch ngọt của cây, được cô đặc nhờ enzyme và bay hơi nước để bảo quản lâu dài. Thành phần chính gồm glucose, fructose, nước và enzyme, kèm theo các hợp chất vi lượng như axit hữu cơ, vitamin, khoáng chất với hoạt tính kháng khuẩn. ","\u003Ch2>Định nghĩa và nguồn gốc\u003C/h2>\u003Cp>Mật ong là sản phẩm tự nhiên được tạo ra bởi ong mật (Apis spp.) từ mật hoa hoặc dịch ngọt của cây. Quá trình hình thành mật ong bao gồm thu nhận nguyên liệu, biến đổi sinh hóa nhờ enzyme và bay hơi nước để đạt độ ẩm tối ưu trước khi lưu trữ trong tổ ong.\u003C/p>\u003Cp>Ong thợ dùng vòi hút mật hoa, lưu trữ tạm thời trong dạ dày mật, nơi enzyme invertase chuyển hóa sucrose thành glucose và fructose. Khi về tổ, mật ong được truyền giữa các cá thể ong thợ, đồng thời ong sử dụng cánh để quạt, tạo luồng không khí làm bay hơi phần lớn nước trong mật.\u003C/p>\u003Cp>Trong tự nhiên, mật ong có thể được phân loại theo nguồn gốc hoa, địa điểm khai thác và điều kiện khí hậu. Ví dụ, mật ong hoa nhãn của vùng Bắc Bộ Việt Nam thường có hương thơm đặc trưng và màu vàng nhạt, trong khi mật ong rừng đậm vị, màu nâu sẫm do đa dạng nguồn hoa.\u003C/p>\u003Ch2>Thành phần hóa học\u003C/h2>\u003Cp>Mật ong chủ yếu gồm carbohydrate đơn và đôi, nước, axit hữu cơ, enzyme và các hợp chất vi lượng. Đường glucose và fructose chiếm tổng cộng từ 68 % đến 83 % khối lượng, trong khi sucrose và oligosaccharide chiếm dưới 5 %.\u003C/p>\u003Cp>Độ ẩm (moisture) là chỉ số quan trọng phản ánh độ tươi và khả năng lên men của mật ong. Công thức tính độ ẩm thường được biểu diễn theo chuẩn:\u003C/p>\u003Cp>\u003Cscript type=\"math/tex\">M = \\frac{\\text{khối lượng nước}}{\\text{khối lượng mẫu}} \\times 100\\%\\end{script> (thường ≤ 20 %).\u003C/p> \u003Ctable> \u003Cthead> \u003Ctr> \u003Cth>Thành phần\u003C/th> \u003Cth>Phạm vi (%)\u003C/th> \u003Cth>Chức năng/đặc tính\u003C/th> \u003C/tr> \u003C/thead> \u003Ctbody> \u003Ctr> \u003Ctd>Fructose\u003C/td> \u003Ctd>38–45\u003C/td> \u003Ctd>Đường đơn ngọt mạnh, dễ hấp thu\u003C/td> \u003C/tr> \u003Ctr> \u003Ctd>Glucose\u003C/td> \u003Ctd>30–38\u003C/td> \u003Ctd>Đường đơn, dễ kết tinh\u003C/td> \u003C/tr> \u003Ctr> \u003Ctd>Sucrose & Oligosaccharide\u003C/td> \u003Ctd>\u003C 5\u003C/td> \u003Ctd>Ảnh hưởng độ ngọt và kết cấu\u003C/td> \u003C/tr> \u003Ctr> \u003Ctd>Độ ẩm\u003C/td> \u003Ctd>17–20\u003C/td> \u003Ctd>Quy định độ bền, khả năng lên men\u003C/td> \u003C/tr> \u003Ctr> \u003Ctd>Enzyme (diastase, glucose oxidase)\u003C/td> \u003Ctd>\u003C 0.5\u003C/td> \u003Ctd>Chất xúc tác sinh hóa, kháng khuẩn\u003C/td> \u003C/tr> \u003Ctr> \u003Ctd>Acid hữu cơ, vitamin, khoáng chất\u003C/td> \u003Ctd>1–3\u003C/td> \u003Ctd>Chống oxy hóa, dinh dưỡng phụ\u003C/td> \u003C/tr> \u003C/tbody> \u003C/table> \u003Cp>Enzyme diastase và glucose oxidase đóng vai trò trong việc duy trì tính kháng khuẩn và chất lượng, trong khi axit hữu cơ và polyphenol góp phần tạo màu, mùi và tác dụng chống oxy hóa.\u003C/p> \u003Ch2>Phân loại và đặc điểm\u003C/h2> \u003Cp>Theo nguồn gốc hoa, mật ong được chia thành nhiều loại: mật ong đơn hoa (monofloral) như hoa nhãn, hoa cà phê, hoa vải; và mật ong đa hoa (polyfloral) thu từ nhiều loài hoa rừng. Mỗi loại cho đặc trưng hương vị, màu sắc và thành phần hóa học khác nhau.\u003C/p> \u003Cp>Theo quy trình khai thác, phân biệt giữa:\u003C/p> \u003Cul> \u003Cli>\u003Cstrong>Mật ong thô (raw honey)\u003C/strong>: Không qua xử lý nhiệt, giữ nguyên enzyme và vi khuẩn có lợi.\u003C/li> \u003Cli>\u003Cstrong>Mật ong tinh chế\u003C/strong>: Lọc kỹ, có thể xử lý nhiệt để loại tinh thể và vi sinh vật, kéo dài thời gian bảo quản.\u003C/li> \u003C/ul> \u003Cp>Màu sắc mật ong dao động từ vàng nhạt đến nâu sẫm, phụ thuộc vào nguồn hoa và hàm lượng khoáng chất. Vùng địa lý cũng ảnh hưởng đáng kể: mật ong rừng núi cao thường đậm màu, ít ngọt dịu hơn so với mật ong đồng bằng.\u003C/p> \u003Ch2>Quy trình khai thác và chế biến\u003C/h2> \u003Cp>Quy trình thu hoạch mật ong bắt đầu bằng việc mở nắp tổ ong và lấy các khay sáp chứa mật. Phần sáp niêm kín cần được loại bỏ cẩn thận để tránh lẫn tạp chất.\u003C/p> \u003Col> \u003Cli>\u003Cstrong>Tách sáp\u003C/strong>: Dùng dao rạch lớp sáp niêm kín từng ô, giữ nguyên cấu trúc tổ để ong tiếp tục sử dụng.\u003C/li> \u003Cli>\u003Cstrong>Thu mật\u003C/strong>: \u003Cul> \u003Cli>Phương pháp ly tâm: Đặt khay vào máy quay li tâm để giải phóng mật mà không làm vỡ sáp.\u003C/li> \u003Cli>Ép thủ công: Dùng khung ép hoặc lưới ép để đẩy mật chảy ra, phù hợp quy mô hộ gia đình.\u003C/li> \u003C/ul> \u003C/li> \u003Cli>\u003Cstrong>Lọc và ổn định\u003C/strong>: Lọc qua vải mịn hoặc lưới nylon để loại tạp chất, sau đó ủ ở nhiệt độ 30–35 °C trong 12–24 giờ để cho tinh thể lơ lửng lắng xuống.\u003C/li> \u003Cli>\u003Cstrong>Đóng gói và bảo quản\u003C/strong>: Đổ mật vào thùng hoặc chai thủy tinh sạch, bảo quản nơi khô ráo, nhiệt độ dưới 25 °C, tránh ánh sáng trực tiếp để ngăn chặn quá trình oxy hóa và lên men.\u003C/li> \u003C/ol> \u003Cp>Trong suốt quá trình, cần kiểm soát độ ẩm, HMF và enzyme diastase để đảm bảo chất lượng theo tiêu chuẩn Codex Alimentarius và quy định của USDA.\u003C/p> \u003Ch2>Chất lượng và phát hiện giả mạo\u003C/h2> \u003Cp>Chất lượng mật ong được đánh giá dựa trên các chỉ tiêu vật lý và hóa học nhằm đảm bảo độ tinh khiết và an toàn. Độ ẩm (moisture) là chỉ số quan trọng, thường đo bằng refractometer, đảm bảo ≤ 20 % để tránh lên men mất chất lượng. Giá trị HMF (hydroxymethylfurfural) phản ánh quá trình phân hủy đường khi bị加 nhiệt hoặc bảo quản lâu, chuẩn ≤ 40 mg/kg theo tiêu chuẩn Codex (\u003Ca href=\"https://www.fao.org/3/y5103e/y5103e06.htm\" target=\"_blank\">FAO\u003C/a>).\u003C/p> \u003Cp>Phân tích đồng vị carbon (δ\u003Csup>13\u003C/sup>C) cho phép phát hiện pha trộn đường thực vật rẻ tiền như syrup ngô hay đường mía. Tỷ lệ \u003Cscript type=\"math/tex\">\\delta^{13}C_{\\text{honey}} - \\delta^{13}C_{\\text{protein}}\u003C/script>&nbsp;lớn hơn ngưỡng ±1‰ chỉ ra sự pha loãng (\u003Ca href=\"https://www.efsa.europa.eu\">EFSA\u003C/a>). Kỹ thuật NMR (nuclear magnetic resonance) cũng được ứng dụng để phân tích dấu vân tay hóa học, phân biệt nguồn gốc hoa và xử lý nhiệt.\u003C/p>\u003Cfigure class=\"table\">\u003Ctable>\u003Cthead>\u003Ctr>\u003Cth>Chỉ tiêu\u003C/th>\u003Cth>Giá trị chuẩn\u003C/th>\u003Cth>Phương pháp phân tích\u003C/th>\u003C/tr>\u003C/thead>\u003Ctbody>\u003Ctr>\u003Ctd>Độ ẩm\u003C/td>\u003Ctd>≤ 20 %\u003C/td>\u003Ctd>Refractometry\u003C/td>\u003C/tr>\u003Ctr>\u003Ctd>HMF\u003C/td>\u003Ctd>≤ 40 mg/kg\u003C/td>\u003Ctd>HPLC–UV\u003C/td>\u003C/tr>\u003Ctr>\u003Ctd>Enzyme diastase\u003C/td>\u003Ctd>≥ 8 Schade units\u003C/td>\u003Ctd>Phổ UV\u003C/td>\u003C/tr>\u003Ctr>\u003Ctd>Đồng vị δ13C\u003C/td>\u003Ctd>Δ ≤ ±1‰\u003C/td>\u003Ctd>IRMS\u003C/td>\u003C/tr>\u003C/tbody>\u003C/table>\u003C/figure>\u003Cp>Việc kiểm soát chất lượng gồm chạy mẫu trắng (blank), mẫu chuẩn tham chiếu (CRM) và mẫu spike recovery để đảm bảo độ chính xác và độ tin cậy; mỗi lô sản phẩm phải được thử nghiệm trước khi đưa ra thị trường.\u003C/p>\u003Ch2>Tính chất sinh học và dinh dưỡng\u003C/h2>\u003Cp>Mật ong giàu các hợp chất sinh học có lợi, bao gồm flavonoid, axit phenolic và enzyme. Flavonoid như quercetin, kaempferol có tác dụng chống oxy hóa, bảo vệ tế bào khỏi tổn thương gốc tự do và giảm viêm (\u003Ca href=\"https://pubmed.ncbi.nlm.nih.gov/26166453/\">NCBI\u003C/a>). Axit gluconic sinh ra từ glucose oxidase làm môi trường pH thấp, ức chế vi khuẩn gây hại.\u003C/p>\u003Cp>Giá trị dinh dưỡng chính đến từ carbohydrate đơn, cung cấp năng lượng nhanh chóng khoảng 300 kcal/100 g. Mật ong cũng chứa khoáng chất (K, Ca, Mg, Zn) và vitamin nhóm B. Các oligosaccharide có khả năng kích thích phát triển vi khuẩn có lợi trong đường ruột, hỗ trợ tiêu hóa và tăng cường miễn dịch.\u003C/p>\u003Cul>\u003Cli>\u003Cstrong>Chống oxy hóa:\u003C/strong> Tỷ lệ tổng phenolic (TPC) trung bình 20–60 mg GAE/100 g.\u003C/li>\u003Cli>\u003Cstrong>Kháng khuẩn:\u003C/strong> Hoạt tính bacteriostatic và bactericidal với Staphylococcus aureus, Escherichia coli.\u003C/li>\u003Cli>\u003Cstrong>Tiêu hóa:\u003C/strong> Fructooligosaccharide (FOS) như prebiotic hỗ trợ hệ vi sinh đường ruột.\u003C/li>\u003C/ul>\u003Ch2>Lợi ích sức khỏe và ứng dụng y học\u003C/h2>\u003Cp>Mật ong từ lâu được dùng trong y học cổ truyền và ngày nay được chứng minh lâm sàng có tác dụng kháng khuẩn, làm lành vết thương và giảm viêm. Gel mật ong Manuka (UMF ≥ 10) được Cục FDA Hoa Kỳ phê duyệt hỗ trợ chữa bỏng và loét da nhờ hàm lượng methylglyoxal cao (\u003Ca href=\"https://www.fda.gov\">FDA\u003C/a>).\u003C/p>\u003Cp>Trong điều trị đường hô hấp, mật ong làm dịu cổ họng, giảm ho khan và cải thiện chất lượng giấc ngủ ở trẻ em và người lớn. Nghiên cứu ngẫu nhiên có đối chứng cho thấy liều 10 g trước giờ ngủ giảm đáng kể số lần ho và mức độ khó chịu (\u003Ca href=\"https://www.nhlbi.nih.gov\">NHLBI\u003C/a>).\u003C/p>\u003Cul>\u003Cli>\u003Cstrong>Hỗ trợ vết thương:\u003C/strong> Tính acid và enzyme sinh H2O2 giữ vết thương sạch, kích thích tái tạo mô.\u003C/li>\u003Cli>\u003Cstrong>Tiêu hóa:\u003C/strong> Giảm viêm dạ dày, hỗ trợ điều trị viêm loét dạ dày khi kết hợp với kháng sinh.\u003C/li>\u003Cli>\u003Cstrong>Miễn dịch:\u003C/strong> Kích thích thực bào và tăng sản xuất cytokine bảo vệ cơ thể.\u003C/li>\u003C/ul>\u003Ch2>Ứng dụng ẩm thực và công nghiệp\u003C/h2>\u003Cp>Trong ẩm thực, mật ong được sử dụng làm chất làm ngọt tự nhiên, thay thế đường tinh luyện và chất tạo ngọt nhân tạo. Hương vị đa dạng của từng loại mật ong giúp gia tăng chiều sâu cho bánh kẹo, nước sốt và đồ uống.\u003C/p>\u003Cp>Công nghiệp thực phẩm khai thác tính hút ẩm và kháng khuẩn của mật ong để cải thiện độ tươi, kéo dài thời gian bảo quản sản phẩm. Mật ong cũng được sử dụng trong sản xuất mứt, kem, và các sản phẩm lên men như mead (rượu mật ong).\u003C/p>\u003Cp>Mỹ phẩm thiên nhiên tận dụng đặc tính giữ ẩm và kháng khuẩn: mặt nạ dưỡng da, son dưỡng môi, kem chống lão hóa. Enzyme và polyphenol trong mật ong giúp làm mềm da, giảm sưng viêm và ngăn ngừa mụn.\u003C/p>\u003Ch2>Danh mục tài liệu tham khảo\u003C/h2>\u003Col>\u003Cli>Food and Agriculture Organization. “Honey: A guide for quality and safety requirements”. FAO, 2018. Retrieved from https://www.fao.org/3/y5103e/y5103e06.htm\u003C/li>\u003Cli>Codex Alimentarius Commission. “Standard for Honey” (CODEX STAN 12-1981). Retrieved from https://www.codexalimentarius.org\u003C/li>\u003Cli>European Food Safety Authority. “Scientific Opinion on the authenticity of honey”. EFSA Journal, 2020. Retrieved from https://www.efsa.europa.eu\u003C/li>\u003Cli>National Honey Board. “Honey Composition and Properties”. 2021. Retrieved from https://www.nationalhoneyboard.org\u003C/li>\u003Cli>Shokri, H., et al. (2016). “Antioxidant and antimicrobial properties of honey”. \u003Ci>Journal of Food Science and Technology\u003C/i>, 53(1), 926–940. https://doi.org/10.1007/s13197-015-2027-z\u003C/li>\u003Cli>FDA. “Manuka Honey and Wound Care”. U.S. Food &amp; Drug Administration, 2017. Retrieved from https://www.fda.gov\u003C/li>\u003Cli>PubMed. “Fructooligosaccharides as prebiotics in honey”. NCBI, 2015. Retrieved from https://pubmed.ncbi.nlm.nih.gov/26166453\u003C/li>\u003C/ol>",{"id":314,"researcherId":17,"name":315,"imageUrl":316},2633,"Hoài Đặng","https://lh3.googleusercontent.com/a/ACg8ocLVXVafUxrnnC_H60UeQdpLE3UgeKGCSesypz_6Vi59B-n9C41A=s96-c",{"id":318,"researcherId":17,"name":319,"imageUrl":320},2681,"Cuong Ta","https://lh3.googleusercontent.com/a/ACg8ocKFuWh0ZD601Hp0_V_2xAK3kIOs20Kyv3V5ZLBo6fwfjyymJYzE=s96-c",[309],"PUBLISHED","2025-06-19T08:17:08.834+00:00","2025-09-10T06:46:56.127+00:00","2025-07-10T01:34:41.386+00:00",125,[328,331,334,337,340,343,346,349,352,355],{"id":329,"title":330},"cá nhân hóa","Cá nhân hóa là gì? Các bài nghiên cứu khoa học liên quan",{"id":332,"title":333},"foxp3","Foxp3 là gì? Các bài báo nghiên cứu khoa học về Foxp3",{"id":335,"title":336},"mô hình rasch","Mô hình rasch là gì? Các bài nghiên cứu khoa học liên quan",{"id":338,"title":339},"giá trị thị trường","Giá trị thị trường là gì? Các nghiên cứu khoa học liên quan",{"id":341,"title":342},"nghiên cứu cảm xúc","Nghiên cứu cảm xúc là gì? Các nghiên cứu Nghiên cứu cảm xúc",{"id":344,"title":345},"l tryptophan","L tryptophan là gì? Các bài nghiên cứu khoa học liên quan",{"id":347,"title":348},"căng thẳng nhiệt","Căng thẳng nhiệt là gì? Các nghiên cứu về Căng thẳng nhiệt",{"id":350,"title":351},"phytase","Phytase là gì? Các bài báo nghiên cứu khoa học liên quan",{"id":353,"title":354},"interferon α","Interferon α là gì? Các nghiên cứu khoa học về Interferon α",{"id":356,"title":357},"bùng nổ","Bùng nổ là gì? Các bài báo nghiên cứu khoa học liên quan",{"meta":359,"data":361},{"total":360},"31759",[362,590,1104,1967,2233,2869,3014,3405,3741,3988],{"id":363,"createTime":364,"updateTime":365,"relativeEntities":366,"slug":367,"properties":368,"entityType":205,"verifyStatus":383,"verifyTime":384,"verifyNote":385,"syncStatus":386,"languages":387,"translateLanguages":389,"viewCount":22,"primaryUrl":391,"fullTextUrl":17,"authors":392,"publicationType":207,"publisherRelationship":415,"citationCount":501,"citationInfo":502,"publishDate":517,"publishYear":518,"citationAnalyzeStatus":386,"lastCitationAnalyze":17,"indexDatabases":17,"openAccess":17,"references":519,"isForceReanalyzing":24},"5044a593-1f93-4afb-b478-580a7b8a9219","2024-07-18T05:54:27.459+00:00","2024-12-24T05:26:39.143+00:00",[],"Density-functional-thermochemistry-III-The-role-of-exact-exchange",{"mag":369,"keywords":371,"openalex":373,"abstract":375,"title":378,"doi":381},{"VOID":370},"2143981217",{"VI":372},"Kohn-Sham, hàm mật độ, trao đổi-tương quan, mật độ quay-lực địa phương, gradient, trao đổi chính xác, năng lượng phân ly, thế ion hóa, ái lực proton, năng lượng nguyên tử",{"VOID":374},"W2143981217",{"EN":376,"VI":377},"\u003Cjats:p>Despite the remarkable thermochemical accuracy of Kohn–Sham density-functional theories with gradient corrections for exchange-correlation [see, for example, A. D. Becke, J. Chem. Phys. 96, 2155 (1992)], we believe that further improvements are unlikely unless exact-exchange information is considered. Arguments to support this view are presented, and a semiempirical exchange-correlation functional containing local-spin-density, gradient, and exact-exchange terms is tested on 56 atomization energies, 42 ionization potentials, 8 proton affinities, and 10 total atomic energies of first- and second-row systems. This functional performs significantly better than previous functionals with gradient corrections only, and fits experimental atomization energies with an impressively small average absolute deviation of 2.4 kcal/mol.\u003C/jats:p>","\u003Cjats:p>Mặc dù lý thuyết hàm mật độ Kohn–Sham với các hiệu chỉnh gradient cho trao đổi-tương quan có độ chính xác nhiệt hoá học đáng kể [xem ví dụ, A. D. Becke, J. Chem. Phys. 96, 2155 (1992)], chúng tôi cho rằng việc cải thiện thêm nữa là khó có thể xảy ra trừ khi thông tin trao đổi chính xác được xem xét. Các lý lẽ hỗ trợ quan điểm này được trình bày và một hàm trọng số trao đổi-tương quan bán thực nghiệm chứa các thuật ngữ về mật độ quay-lực địa phương, gradient và trao đổi chính xác đã được thử nghiệm trên 56 năng lượng phân ly, 42 thế ion hoá, 8 ái lực proton và 10 tổng năng lượng nguyên tử của các hệ hàng thứ nhất và thứ hai. Hàm này hoạt động tốt hơn đáng kể so với các hàm trước đó chỉ có các hiệu chỉnh gradient và khớp với các năng lượng phân ly thực nghiệm với độ lệch tuyệt đối trung bình ấn tượng chỉ là 2.4 kcal/mol.\u003C/jats:p>",{"EN":379,"VI":380},"Density-functional thermochemistry. III. The role of exact exchange","Nhiệt hoá học hàm mật độ. III. Vai trò của trao đổi chính xác",{"VOID":382},"10.1063/1.464913","VERIFIED","2024-07-18T05:54:27.458+00:00","Auto Verify","PENDING",[388],"EN",[390],"VI","https://pubs.aip.org/jcp/article/98/7/5648/842114/Density-functional-thermochemistry-III-The-role-of",[393],{"id":394,"sortIndex":22,"researcher":17,"roles":395,"affiliations":396,"properties":408},"648864b8-19fa-4d38-9fb3-5c6d3bbb163a",[],[397],{"id":398,"sortIndex":22,"affiliation":399,"properties":17},"7dc7ec40-6f92-449d-a39e-a7efbae04231",{"id":400,"createTime":401,"updateTime":402,"relativeEntities":403,"slug":404,"properties":405,"entityType":21,"verifyStatus":386,"verifyTime":17,"verifyNote":17,"syncStatus":386,"languages":17,"translateLanguages":17,"viewCount":22},"b0f585ad-3be5-41e7-a79d-d634b5377e8e","2024-01-15T07:31:20.428+00:00","2024-12-06T04:15:16.459+00:00",[],"Department-of-Chemistry-Queen-s-University-Kingston-Ontario-Canada-K7L-3N6",{"title":406},{"VI":407},"Department of Chemistry, Queen's University, Kingston, Ontario, Canada K7L 3N6",{"openalex":409,"orcid":411,"title":413},{"VOID":410},"A5015077264",{"VOID":412},"https://orcid.org/0000-0002-6668-7728",{"EN":414},"Axel D. Becke",{"url":17,"publisher":416,"properties":494},{"id":417,"createTime":418,"updateTime":419,"relativeEntities":420,"slug":421,"properties":422,"entityType":153,"verifyStatus":386,"verifyTime":17,"verifyNote":17,"syncStatus":386,"languages":17,"translateLanguages":17,"viewCount":22,"subjectFields":433,"manageAffiliations":434,"indexDatabases":435,"url":477,"thumbnailPath":17,"statistic":478,"gsStatistic":17,"type":17,"analyzePriority":17},"b27a65e0-e677-4c05-9546-5a82122191e4","2023-05-29T10:40:18.930+00:00","2025-02-11T05:15:36.972+00:00",[],"Journal-of-Chemical-Physics",{"country":423,"issn":425,"introduce":427,"eissn":429,"title":431},{"VOID":424},"US",{"VOID":426},"10897690",{"EN":428},"The Journal of Chemical Physics publishes quantitative and rigorous science of long-lasting value in methods and applications of chemical physics. The Journal also publishes brief Communications of significant new findings, Perspectives on the latest advances in the field, and Special Topic issues. The Journal focuses on innovative research in experimental and theoretical areas of chemical physics, including spectroscopy, dynamics, kinetics, statistical mechanics, and quantum mechanics. In addition, topical areas such as polymers, soft matter, materials, surfaces/interfaces, and systems of biological relevance are of increasing importance. Topical coverage includes: Theoretical Methods and Algorithms Advanced Experimental Techniques Atoms, Molecules, and Clusters Liquids, Glasses, and Crystals Surfaces, Interfaces, and Materials Polymers and Soft Matter Biological Molecules and Networks.",{"VOID":430},"00219606",{"EN":432},"Journal of Chemical Physics",[],[],[436,456],{"id":437,"indexDatabase":438,"url":450,"indexYears":451,"academicFieldIds":452},"a54f8fec-e3a1-4a0a-89f7-9c60c0145e2d",{"id":439,"createTime":440,"updateTime":441,"relativeEntities":442,"label":443,"description":445,"key":447,"publicationTags":448,"standard":17},"3c7051d4-eb7d-4c57-a56b-36fc74c5d1e9","2023-05-22T09:57:18.509+00:00","2025-07-10T09:55:58.024+00:00",[],{"EN":444,"VI":444},"Scopus - Elsevier",{"EN":444,"VI":446},"Cơ sở dữ liệu Scopus thuộc Elsevier","scopus",[449],"SCOPUS","https://www.scopus.com/sourceid/28134","1933-2023",[453,454,455],"0c2541d6-7567-4793-aad8-840b3d33f5e0","e89cebf4-fecf-4b74-8ab4-88fca891e4c2","b4efb51f-da98-4990-a79e-a5f531f11b28",{"id":457,"indexDatabase":458,"url":472,"indexYears":17,"academicFieldIds":473},"10841295-20fc-4732-836c-b22051fdb593",{"id":459,"createTime":460,"updateTime":461,"relativeEntities":462,"label":463,"description":465,"key":468,"publicationTags":469,"standard":17},"a4921856-b128-4d9f-8f1f-e80813d3bbd4","2023-05-22T09:59:31.026+00:00","2025-01-14T09:58:12.199+00:00",[],{"EN":464,"VI":464},"ISI/SCIE - Science Citation Index Expanded",{"VI":466,"EN":467},"Cơ sở dữ liệu SCIE","SCIE database","scie",[470,471],"SCIE","ISI","https://mjl.clarivate.com/search-results?issn=0021-9606",[474,475,476],"bb53981f-29b6-4b16-89ea-99cf1e4357c7","d6c3d63f-ea74-46da-84a0-f1951ff6d9b8","1f780287-8dee-4820-a6a9-dc25c634f349","https://aip.scitation.org/journal/jcp",{"impactFactor":22,"impactFactorByYear":479,"i10Index":481,"i10IndexLast5Year":22,"totalPublication":481,"totalPublicationByYear":483,"totalCitation":484,"totalCitationByYear":485,"totalCitationPerPublication":491,"totalCitationPerPublicationByYear":492,"hindexLast5Year":481,"hindex":481},{"1995":71,"1996":480,"2015":481,"2016":482},2.33,6,10,{"1994":34,"1995":47,"2001":34,"2002":34,"2014":34},241,{"1994":486,"1995":487,"2001":488,"2002":489,"2014":490},25,132,16,24,44,40.17,{"1994":486,"1995":493,"2001":488,"2002":489,"2014":490},66,{"volume":495,"pages":497,"issue":499},{"VOID":496},"98",{"VOID":498},"5648-5652",{"VOID":500},"7",91520,{"total":501,"publishYear":17,"statisticByYear":503},{"2012":504,"2013":505,"2014":506,"2015":507,"2016":508,"2017":509,"2018":510,"2019":511,"2020":512,"2021":513,"2022":514,"2023":515,"2024":516},4374,4499,4690,4715,4618,4570,4471,4549,4406,4351,4271,4178,2200,"1993-04-01",1993,[520,524,528,532,536,538,542,544,548,550,554,558,562,566,570,572,576,580,583,586],{"id":17,"text":521,"url":17,"identifiers":522},"1989, J. Chem. Phys., 90, 5622, 10.1063/1.456415",{"doi":523},"10.1063/1.456415",{"id":17,"text":525,"url":17,"identifiers":526},"1990, J. Chem. Phys., 93, 2537, 10.1063/1.458892",{"doi":527},"10.1063/1.458892",{"id":17,"text":529,"url":17,"identifiers":530},"1992, J. Chem. Phys., 96, 2155, 10.1063/1.462066",{"doi":531},"10.1063/1.462066",{"id":17,"text":533,"url":17,"identifiers":534},"1988, Phys. Rev. A, 38, 3098, 10.1103/PhysRevA.38.3098",{"doi":535},"10.1103/PhysRevA.38.3098",{"id":17,"text":15,"url":17,"identifiers":537},{},{"id":17,"text":539,"url":17,"identifiers":540},"1992, J. Chem. Phys., 97, 9173, 10.1063/1.463343",{"doi":541},"10.1063/1.463343",{"id":17,"text":15,"url":17,"identifiers":543},{},{"id":17,"text":545,"url":17,"identifiers":546},"1992, Phys. Rev. B, 46, 6671, 10.1103/PhysRevB.46.6671",{"doi":547},"10.1103/PhysRevB.46.6671",{"id":17,"text":15,"url":17,"identifiers":549},{},{"id":17,"text":551,"url":17,"identifiers":552},"1974, J. Phys. F, 4, 1170, 10.1088/0305-4608/4/8/013",{"doi":553},"10.1088/0305-4608/4/8/013",{"id":17,"text":555,"url":17,"identifiers":556},"1976, Phys. Rev. B, 13, 4274, 10.1103/PhysRevB.13.4274",{"doi":557},"10.1103/PhysRevB.13.4274",{"id":17,"text":559,"url":17,"identifiers":560},"1977, Phys. Rev. B, 15, 2884, 10.1103/PhysRevB.15.2884",{"doi":561},"10.1103/PhysRevB.15.2884",{"id":17,"text":563,"url":17,"identifiers":564},"1984, Phys. Rev. A, 29, 1648, 10.1103/PhysRevA.29.1648",{"doi":565},"10.1103/PhysRevA.29.1648",{"id":17,"text":567,"url":17,"identifiers":568},"1993, J. Chem. Phys., 98, 1372, 10.1063/1.464304",{"doi":569},"10.1063/1.464304",{"id":17,"text":15,"url":17,"identifiers":571},{},{"id":17,"text":573,"url":17,"identifiers":574},"1988, J. Chem. Phys., 88, 1053, 10.1063/1.454274",{"doi":575},"10.1063/1.454274",{"id":17,"text":577,"url":17,"identifiers":578},"1985, Phys. Rev. B, 31, 7588, 10.1103/PhysRevB.31.7588",{"doi":579},"10.1103/PhysRevB.31.7588",{"id":17,"text":581,"url":17,"identifiers":582},"1992, Phys. Rev. B, 45, 13",{},{"id":17,"text":584,"url":17,"identifiers":585},"1992, Int. J. Quantum Chem. Quantum Chem. Symp., 26, 319",{},{"id":17,"text":587,"url":17,"identifiers":588},"1991, J. Chem. Phys., 94, 7221, 10.1063/1.460205",{"doi":589},"10.1063/1.460205",{"id":591,"createTime":592,"updateTime":593,"relativeEntities":594,"slug":595,"properties":596,"entityType":205,"verifyStatus":383,"verifyTime":592,"verifyNote":385,"syncStatus":386,"languages":612,"translateLanguages":613,"viewCount":22,"primaryUrl":614,"fullTextUrl":17,"authors":615,"publicationType":207,"publisherRelationship":748,"citationCount":841,"citationInfo":842,"publishDate":852,"publishYear":853,"citationAnalyzeStatus":386,"lastCitationAnalyze":17,"indexDatabases":17,"openAccess":17,"references":854,"isForceReanalyzing":24},"8e120c56-1ac2-4006-a5b0-be0506d49114","2024-09-04T23:11:07.790+00:00","2024-12-30T02:49:24.738+00:00",[],"Global-cancer-statistics-2018-GLOBOCAN-estimates-of-incidence-and-mortality-worldwide-for-36-cancers-in-185-countries",{"mag":597,"keywords":599,"openalex":600,"abstract":602,"title":605,"pm":608,"doi":610},{"VOID":598},"2889646458",{"VI":15},{"VOID":601},"W2889646458",{"EN":603,"VI":604},"\u003Cjats:title>Abstract\u003C/jats:title>\u003Cjats:p>This article provides a status report on the global burden of cancer worldwide using the GLOBOCAN 2018 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer, with a focus on geographic variability across 20 world regions. There will be an estimated 18.1 million new cancer cases (17.0 million excluding nonmelanoma skin cancer) and 9.6 million cancer deaths (9.5 million excluding nonmelanoma skin cancer) in 2018. In both sexes combined, lung cancer is the most commonly diagnosed cancer (11.6% of the total cases) and the leading cause of cancer death (18.4% of the total cancer deaths), closely followed by female breast cancer (11.6%), prostate cancer (7.1%), and colorectal cancer (6.1%) for incidence and colorectal cancer (9.2%), stomach cancer (8.2%), and liver cancer (8.2%) for mortality. Lung cancer is the most frequent cancer and the leading cause of cancer death among males, followed by prostate and colorectal cancer (for incidence) and liver and stomach cancer (for mortality). Among females, breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death, followed by colorectal and lung cancer (for incidence), and vice versa (for mortality); cervical cancer ranks fourth for both incidence and mortality. The most frequently diagnosed cancer and the leading cause of cancer death, however, substantially vary across countries and within each country depending on the degree of economic development and associated social and life style factors. It is noteworthy that high‐quality cancer registry data, the basis for planning and implementing evidence‐based cancer control programs, are not available in most low‐ and middle‐income countries. The Global Initiative for Cancer Registry Development is an international partnership that supports better estimation, as well as the collection and use of local data, to prioritize and evaluate national cancer control efforts. \u003Cjats:bold>CA: A Cancer Journal for Clinicians 2018;0:1‐31.\u003C/jats:bold> © 2018 American Cancer Society\u003C/jats:p>","\u003Cjats:title>Tóm tắt\u003C/jats:title>\u003Cjats:p>Bài viết này cung cấp một báo cáo tình trạng về gánh nặng ung thư toàn cầu dựa trên các ước tính về tỷ lệ mắc và tỷ lệ tử vong do ung thư GLOBOCAN 2018 do Cơ quan Quốc tế Nghiên cứu Ung thư thực hiện, với trọng tâm là sự biến đổi địa lý qua 20 vùng trên thế giới. Dự kiến sẽ có 18,1 triệu ca ung thư mới (17,0 triệu không bao gồm ung thư da không melanin) và 9,6 triệu ca tử vong do ung thư (9,5 triệu không bao gồm ung thư da không melanin) vào năm 2018. Trung bình hai giới tính, ung thư phổi là loại ung thư thường được chẩn đoán nhất (chiếm 11,6% tổng số ca) và là nguyên nhân hàng đầu gây tử vong do ung thư (chiếm 18,4% tổng số ca tử vong do ung thư), tiếp theo là ung thư vú ở nữ (11,6%), ung thư tuyến tiền liệt (7,1%), và ung thư đại trực tràng (6,1%) về tỷ lệ mắc và ung thư đại trực tràng (9,2%), ung thư dạ dày (8,2%), và ung thư gan (8,2%) về tỷ lệ tử vong. Ung thư phổi là loại ung thư phổ biến nhất và là nguyên nhân hàng đầu gây tử vong do ung thư ở nam giới, tiếp theo là ung thư tuyến tiền liệt và ung thư đại trực tràng (về tỷ lệ mắc) cũng như ung thư gan và ung thư dạ dày (về tỷ lệ tử vong). Ở nữ giới, ung thư vú là loại ung thư thường được chẩn đoán nhất và là nguyên nhân hàng đầu gây tử vong, tiếp theo là ung thư đại trực tràng và ung thư phổi (về tỷ lệ mắc), và ngược lại (về tỷ lệ tử vong); ung thư cổ tử cung đứng thứ tư về cả tỷ lệ mắc và tỷ lệ tử vong. Tuy nhiên, loại ung thư thường được chẩn đoán nhất và nguyên nhân hàng đầu gây tử vong do ung thư thay đổi đáng kể giữa các quốc gia và trong mỗi quốc gia tùy thuộc vào mức độ phát triển kinh tế và các yếu tố xã hội, lối sống liên quan. Đáng lưu ý rằng dữ liệu đăng ký ung thư chất lượng cao, cơ sở cho việc lập kế hoạch và triển khai các chương trình kiểm soát ung thư dựa trên chứng cứ, không có sẵn ở hầu hết các quốc gia thu nhập thấp và trung bình. Sáng kiến ​​Toàn cầu về Phát triển Đăng ký Ung thư là một đối tác quốc tế hỗ trợ việc ước tính tốt hơn, cũng như việc thu thập và sử dụng dữ liệu địa phương, để ưu tiên và đánh giá các nỗ lực kiểm soát ung thư quốc gia. \u003Cjats:bold>CA: Tạp chí Ung thư cho Các Nhà Lâm Sàng 2018;0:1‐31.\u003C/jats:bold> © 2018 Hiệp hội Ung thư Hoa Kỳ\u003C/jats:p>",{"EN":606,"VI":607},"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","Thống kê ung thư toàn cầu 2018: Dự đoán về tỷ lệ mắc và tỷ lệ tử vong trên toàn thế giới cho 36 loại ung thư tại 185 quốc gia",{"VOID":609},"30207593",{"VOID":611},"10.3322/caac.21492",[388],[390],"https://acsjournals.onlinelibrary.wiley.com/doi/10.3322/caac.21492",[616,638,660,681,703,726],{"id":617,"sortIndex":22,"researcher":17,"roles":618,"affiliations":619,"properties":631},"4adbe498-0ff6-4f85-b78e-3f530e7c0c2e",[],[620],{"id":621,"sortIndex":22,"affiliation":622,"properties":17},"664ee268-5c4f-4024-af6a-55a7a8c0634a",{"id":623,"createTime":624,"updateTime":625,"relativeEntities":626,"slug":627,"properties":628,"entityType":21,"verifyStatus":386,"verifyTime":17,"verifyNote":17,"syncStatus":386,"languages":17,"translateLanguages":17,"viewCount":22},"3c401113-46e8-49fd-977d-d504beb83297","2024-09-01T04:34:39.474+00:00","2024-09-22T05:24:30.123+00:00",[],"Head-Section-of-Cancer-Surveillance-International-Agency-for-Research-on-Cancer-Lyon-France",{"title":629},{"EN":630},"Head, Section of Cancer Surveillance International Agency for Research on Cancer Lyon France",{"openalex":632,"orcid":634,"title":636},{"VOID":633},"A5064215217",{"VOID":635},"https://orcid.org/0000-0002-3248-7787",{"EN":637},"Freddie Bray",{"id":639,"sortIndex":58,"researcher":17,"roles":640,"affiliations":641,"properties":653},"2761a369-0f0a-44d7-9005-30ed1043653e",[],[642],{"id":643,"sortIndex":22,"affiliation":644,"properties":17},"2cbb6043-d6d8-4ade-a77c-ff77dced21d6",{"id":645,"createTime":646,"updateTime":647,"relativeEntities":648,"slug":649,"properties":650,"entityType":21,"verifyStatus":386,"verifyTime":17,"verifyNote":17,"syncStatus":386,"languages":17,"translateLanguages":17,"viewCount":22},"862834bb-7972-42f5-a660-8de814e7853e","2024-09-04T23:11:07.844+00:00","2024-09-23T19:55:32.399+00:00",[],"Scientific-Director-Surveillance-and-Health-Services-Research-American-Cancer-Society-Atlanta-GA",{"title":651},{"EN":652},"Scientific Director Surveillance and Health Services Research, American Cancer Society Atlanta GA",{"openalex":654,"orcid":656,"title":658},{"VOID":655},"A5047300895",{"VOID":657},"https://orcid.org/0000-0001-5247-8522",{"EN":659},"Rebecca L. 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Accessed June 21 2018.",{},{"id":17,"text":1051,"url":17,"identifiers":1052},"10.1158/1055-9965.EPI-05-0231",{"doi":1051},{"id":17,"text":1054,"url":17,"identifiers":1055},"10.1158/1055-9965.EPI-04-0569",{"doi":1054},{"id":17,"text":1057,"url":17,"identifiers":1058},"10.1016/j.vaccine.2013.02.071",{"doi":1057},{"id":17,"text":1060,"url":17,"identifiers":1061},"10.1002/ijc.30901",{"doi":1060},{"id":17,"text":1063,"url":17,"identifiers":1064},"10.1016/S0140-6736(13)62218-7",{"doi":1063},{"id":17,"text":1066,"url":17,"identifiers":1067},"10.1016/j.ijgo.2015.02.014",{"doi":1066},{"id":17,"text":1069,"url":17,"identifiers":1070},"Thun MJ, 2018, Cancer Epidemiology and Prevention, 1193",{},{"id":17,"text":1072,"url":17,"identifiers":1073},"10.1038/nrclinonc.2015.146",{"doi":1072},{"id":17,"text":1075,"url":17,"identifiers":1076},"Kitahara CM, 2018, Cancer Epidemiology and Prevention, 839",{},{"id":17,"text":1078,"url":17,"identifiers":1079},"Silverman DT, 2018, Cancer Epidemiology and Prevention, 977",{},{"id":17,"text":1081,"url":17,"identifiers":1082},"10.1001/jama.2011.1142",{"doi":1081},{"id":17,"text":1084,"url":17,"identifiers":1085},"10.3322/caac.21440",{"doi":1084},{"id":17,"text":1087,"url":17,"identifiers":1088},"10.1080/0284186X.2016.1197419",{"doi":1087},{"id":17,"text":1090,"url":17,"identifiers":1091},"10.1002/ijc.31088",{"doi":1090},{"id":17,"text":1093,"url":17,"identifiers":1094},"10.1038/s41416-018-0029-6",{"doi":1093},{"id":17,"text":1096,"url":17,"identifiers":1097},"10.1093/epirev/mxx003",{"doi":1096},{"id":17,"text":1099,"url":17,"identifiers":1100},"10.1007/s10147-008-0762-6",{"doi":1099},{"id":17,"text":1102,"url":17,"identifiers":1103},"10.1016/S0140-6736(15)00135-X",{"doi":1102},{"id":1105,"createTime":1106,"updateTime":1107,"relativeEntities":1108,"slug":1109,"properties":1110,"entityType":205,"verifyStatus":383,"verifyTime":1106,"verifyNote":385,"syncStatus":386,"languages":1126,"translateLanguages":1127,"viewCount":22,"primaryUrl":1128,"fullTextUrl":17,"authors":1129,"publicationType":207,"publisherRelationship":1243,"citationCount":825,"citationInfo":1281,"publishDate":1288,"publishYear":1289,"citationAnalyzeStatus":386,"lastCitationAnalyze":17,"indexDatabases":17,"openAccess":17,"references":1290,"isForceReanalyzing":24},"f5b8c552-4bbc-4038-83f7-83fb8bf49ccf","2024-09-12T21:57:55.024+00:00","2024-12-30T02:51:20.645+00:00",[],"Global-Cancer-Statistics-2020-GLOBOCAN-Estimates-of-Incidence-and-Mortality-Worldwide-for-36-Cancers-in-185-Countries",{"mag":1111,"keywords":1113,"openalex":1114,"abstract":1116,"title":1119,"pm":1122,"doi":1124},{"VOID":1112},"3128646645",{"VI":15},{"VOID":1115},"W3128646645",{"EN":1117,"VI":1118},"\u003Cjats:title>Abstract\u003C/jats:title>\u003Cjats:p>This article provides an update on the global cancer burden using the GLOBOCAN 2020 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer. Worldwide, an estimated 19.3 million new cancer cases (18.1 million excluding nonmelanoma skin cancer) and almost 10.0 million cancer deaths (9.9 million excluding nonmelanoma skin cancer) occurred in 2020. Female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer, with an estimated 2.3 million new cases (11.7%), followed by lung (11.4%), colorectal (10.0 %), prostate (7.3%), and stomach (5.6%) cancers. Lung cancer remained the leading cause of cancer death, with an estimated 1.8 million deaths (18%), followed by colorectal (9.4%), liver (8.3%), stomach (7.7%), and female breast (6.9%) cancers. Overall incidence was from 2‐fold to 3‐fold higher in transitioned versus transitioning countries for both sexes, whereas mortality varied &lt;2‐fold for men and little for women. Death rates for female breast and cervical cancers, however, were considerably higher in transitioning versus transitioned countries (15.0 vs 12.8 per 100,000 and 12.4 vs 5.2 per 100,000, respectively). The global cancer burden is expected to be 28.4 million cases in 2040, a 47% rise from 2020, with a larger increase in transitioning (64% to 95%) versus transitioned (32% to 56%) countries due to demographic changes, although this may be further exacerbated by increasing risk factors associated with globalization and a growing economy. Efforts to build a sustainable infrastructure for the dissemination of cancer prevention measures and provision of cancer care in transitioning countries is critical for global cancer control.\u003C/jats:p>","\u003Cjats:title>Tóm tắt\u003C/jats:title>\u003Cjats:p>Bài báo này cung cấp thông tin cập nhật về gánh nặng ung thư toàn cầu dựa trên các ước tính về tỷ lệ mắc và tử vong do ung thư từ GLOBOCAN 2020, được sản xuất bởi Cơ quan Quốc tế về Nghiên cứu Ung thư. Trên toàn thế giới, ước tính có 19,3 triệu ca ung thư mới (18,1 triệu ca không bao gồm ung thư da không phải tế bào sắc tố) và gần 10 triệu ca tử vong vì ung thư (9,9 triệu ca không bao gồm ung thư da không phải tế bào sắc tố) vào năm 2020. Ung thư vú ở nữ giới đã vượt qua ung thư phổi trở thành loại ung thư được chẩn đoán phổ biến nhất, với ước tính 2,3 triệu ca mới (11,7%), tiếp theo là ung thư phổi (11,4%), ung thư đại trực tràng (10,0%), ung thư tuyến tiền liệt (7,3%) và ung thư dạ dày (5,6%). Ung thư phổi tiếp tục là nguyên nhân hàng đầu gây tử vong do ung thư, với ước tính 1,8 triệu ca tử vong (18%), tiếp theo là ung thư đại trực tràng (9,4%), ung thư gan (8,3%), ung thư dạ dày (7,7%) và ung thư vú ở nữ (6,9%). Tỷ lệ mắc bệnh chung cao gấp từ 2 đến 3 lần ở các quốc gia đã chuyển đổi so với các quốc gia đang chuyển đổi cho cả hai giới, trong khi tỷ lệ tử vong thay đổi \u003C2 lần đối với nam giới và ít đối với nữ giới. Tuy nhiên, tỷ lệ tử vong do ung thư vú và ung thư cổ tử cung ở nữ giới lại cao hơn đáng kể ở các quốc gia đang chuyển đổi so với các quốc gia đã chuyển đổi (15,0 so với 12,8 trên 100.000 và 12,4 so với 5,2 trên 100.000, tương ứng). Gánh nặng ung thư toàn cầu dự kiến sẽ đạt 28,4 triệu ca vào năm 2040, tăng 47% so với năm 2020, với mức tăng cao hơn ở các quốc gia đang chuyển đổi (64% đến 95%) so với các quốc gia đã chuyển đổi (32% đến 56%) do các thay đổi nhân khẩu học, mặc dù điều này có thể bị ảnh hưởng thêm bởi sự gia tăng các yếu tố rủi ro liên quan đến toàn cầu hóa và nền kinh tế phát triển. Những nỗ lực xây dựng một cơ sở hạ tầng bền vững để phổ biến các biện pháp phòng ngừa ung thư và cung cấp dịch vụ chăm sóc ung thư tại các quốc gia đang chuyển đổi là rất quan trọng để kiểm soát ung thư toàn cầu.\u003C/jats:p>",{"EN":1120,"VI":1121},"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","Thống kê Ung thư Toàn cầu 2020: Ước tính GLOBOCAN về Tỷ lệ Incidence và Tử vong trên Toàn thế giới đối với 36 Loại Ung thư ở 185 Quốc gia",{"VOID":1123},"33538338",{"VOID":1125},"10.3322/caac.21660",[388],[390],"https://acsjournals.onlinelibrary.wiley.com/doi/10.3322/caac.21660",[1130,1152,1170,1187,1201,1215,1229],{"id":1131,"sortIndex":58,"researcher":17,"roles":1132,"affiliations":1133,"properties":1145},"4fe06282-afbe-46da-8e55-ee3bf0789d0c",[],[1134],{"id":1135,"sortIndex":22,"affiliation":1136,"properties":17},"0777aa91-0345-48f8-a51f-72fe500b2a34",{"id":1137,"createTime":1138,"updateTime":1139,"relativeEntities":1140,"slug":1141,"properties":1142,"entityType":21,"verifyStatus":386,"verifyTime":17,"verifyNote":17,"syncStatus":386,"languages":17,"translateLanguages":17,"viewCount":22},"1a91b744-09c7-418a-b037-dcce8bf5d2de","2024-01-25T23:21:29.801+00:00","2024-11-25T20:23:09.851+00:00",[],"Section-of-Cancer-Surveillance-International-Agency-for-Research-on-Cancer-Lyon-France",{"title":1143},{"VI":1144},"Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, 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Health Scotland.Scottish Cancer Registry. 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We have developed Trimmomatic as a more flexible and efficient preprocessing tool, which could correctly handle paired-end data.\u003C/jats:p>\n \u003Cjats:p>Results: The value of NGS read preprocessing is demonstrated for both reference-based and reference-free tasks. Trimmomatic is shown to produce output that is at least competitive with, and in many cases superior to, that produced by other tools, in all scenarios tested.\u003C/jats:p>\n \u003Cjats:p>Availability and implementation: Trimmomatic is licensed under GPL V3. It is cross-platform (Java 1.5+ required) and available at http://www.usadellab.org/cms/index.php?page=trimmomatic\u003C/jats:p>\n \u003Cjats:p>Contact:  usadel@bio1.rwth-aachen.de\u003C/jats:p>\n \u003Cjats:p>Supplementary information:  Supplementary data are available at Bioinformatics online.\u003C/jats:p>","\u003Cjats:title>Tóm tắt\u003C/jats:title>\n \u003Cjats:p>Động lực: Mặc dù đã có nhiều công cụ xử lý dữ liệu đọc từ giải trình tự thế hệ mới (NGS), chúng tôi vẫn không tìm thấy công cụ nào hoặc sự kết hợp của các công cụ đáp ứng yêu cầu của chúng tôi về tính linh hoạt, khả năng xử lý chính xác dữ liệu cặp đầu và hiệu suất cao. Chúng tôi đã phát triển Trimmomatic như một công cụ xử lý dữ liệu đầu vào linh hoạt và hiệu quả hơn, có khả năng xử lý chính xác dữ liệu cặp đầu.\u003C/jats:p>\n \u003Cjats:p>Kết quả: Giá trị của việc xử lý dữ liệu đọc NGS đã được chứng minh cả trong các tác vụ dựa trên tham chiếu và không dựa trên tham chiếu. Trimmomatic cho thấy sản phẩm đầu ra ít nhất là ngang bằng, và trong nhiều trường hợp còn vượt trội hơn, so với các công cụ khác trong tất cả các kịch bản đã được kiểm nghiệm.\u003C/jats:p>\n \u003Cjats:p>Tính khả dụng và triển khai: Trimmomatic được cấp phép theo GPL V3. Công cụ này có thể chạy trên nhiều nền tảng (cần Java 1.5+) và có sẵn tại http://www.usadellab.org/cms/index.php?page=trimmomatic\u003C/jats:p>\n \u003Cjats:p>Liên hệ: usadel@bio1.rwth-aachen.de\u003C/jats:p>\n \u003Cjats:p>Thông tin bổ sung: Dữ liệu bổ sung có sẵn trực tuyến tại Bioinformatics.\u003C/jats:p>",{"EN":1985,"VI":1986},"Trimmomatic: a flexible trimmer for Illumina sequence data","Trimmomatic: một công cụ cắt linh hoạt cho dữ liệu chuỗi Illumina",{"VOID":1988},"24695404",{"VOID":1990},"10.1093/bioinformatics/btu170","2024-09-01T04:57:04.553+00:00",[388],[390],"https://academic.oup.com/bioinformatics/article/30/15/2114/2390096",[1996,2017,2034],{"id":1997,"sortIndex":34,"researcher":17,"roles":1998,"affiliations":1999,"properties":2010},"d07dfef3-a893-4c25-b015-7e20fb8042ac",[],[2000],{"id":2001,"sortIndex":22,"affiliation":2002,"properties":17},"6ff44e04-25d0-42a2-8335-64a8e8f4577c",{"id":2003,"createTime":2004,"updateTime":2004,"relativeEntities":2005,"slug":2006,"properties":2007,"entityType":21,"verifyStatus":386,"verifyTime":17,"verifyNote":17,"syncStatus":386,"languages":17,"translateLanguages":17,"viewCount":22},"191ca322-9135-424e-a64c-a5b89422db91","2024-09-01T04:57:04.568+00:00",[],"1-Department-Metabolic-Networks-Max-Planck-Institute-of-Molecular-Plant-Physiology-Am-M%C3%BChlenberg-1-14476-Golm-2-Institut-f%C3%BCr-Biologie-I-RWTH-Aachen-Worringer-Weg-3-52074-Aachen-and-3-Institute-of-Bio-and-Geosciences-Plant-Sciences-Forschungszentrum-J%C3%BClich-Leo-Brandt-Stra%C3%9Fe-52425-J%C3%BClich-Germany",{"title":2008},{"EN":2009},"1 Department Metabolic Networks, Max Planck Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14476 Golm, 2 Institut für Biologie I, RWTH Aachen, Worringer Weg 3, 52074 Aachen and 3 Institute of Bio- and Geosciences: Plant Sciences, Forschungszentrum Jülich, Leo-Brandt-Straße, 52425 Jülich, Germany",{"openalex":2011,"orcid":2013,"title":2015},{"VOID":2012},"A5068353394",{"VOID":2014},"https://orcid.org/0009-0005-7498-7279",{"EN":2016},"Marc Lohse",{"id":2018,"sortIndex":47,"researcher":17,"roles":2019,"affiliations":2020,"properties":2027},"6c803e9a-f814-4b5a-bef6-c62079d7d4a3",[],[2021],{"id":2022,"sortIndex":22,"affiliation":2023,"properties":17},"1907d7ac-2e52-49c4-91f7-6b9cead68484",{"id":2003,"createTime":2004,"updateTime":2004,"relativeEntities":2024,"slug":2006,"properties":2025,"entityType":21,"verifyStatus":386,"verifyTime":17,"verifyNote":17,"syncStatus":386,"languages":17,"translateLanguages":17,"viewCount":22},[],{"title":2026},{"EN":2009},{"openalex":2028,"orcid":2030,"title":2032},{"VOID":2029},"A5011858960",{"VOID":2031},"https://orcid.org/0000-0003-0921-8041",{"EN":2033},"Björn Usadel",{"id":2035,"sortIndex":22,"researcher":17,"roles":2036,"affiliations":2037,"properties":2044},"e989725e-01d1-4a1b-8a37-b867feec20be",[],[2038],{"id":2039,"sortIndex":22,"affiliation":2040,"properties":17},"1db8cf32-3a7c-4730-910f-102ef2748c76",{"id":2003,"createTime":2004,"updateTime":2004,"relativeEntities":2041,"slug":2006,"properties":2042,"entityType":21,"verifyStatus":386,"verifyTime":17,"verifyNote":17,"syncStatus":386,"languages":17,"translateLanguages":17,"viewCount":22},[],{"title":2043},{"EN":2009},{"openalex":2045,"title":2047},{"VOID":2046},"A5027039912",{"EN":2048},"Anthony Bolger",{"url":17,"publisher":2050,"properties":2169},{"id":2051,"createTime":2052,"updateTime":2053,"relativeEntities":2054,"slug":2055,"properties":2056,"entityType":153,"verifyStatus":386,"verifyTime":17,"verifyNote":17,"syncStatus":386,"languages":17,"translateLanguages":17,"viewCount":22,"subjectFields":2066,"manageAffiliations":2067,"indexDatabases":2068,"url":2097,"thumbnailPath":17,"statistic":2098,"gsStatistic":17,"type":17,"analyzePriority":17},"6624d7c2-f227-440b-b1ed-9ff88a3948fe","2023-05-29T10:28:09.117+00:00","2025-01-26T03:59:42.712+00:00",[],"Bioinformatics",{"country":2057,"issn":2059,"introduce":2061,"eissn":2063,"title":2065},{"VOID":2058},"GB",{"VOID":2060},"13674803",{"EN":2062},"The leading journal in its field, Bioinformatics publishes the highest quality scientific papers and review articles of interest to academic and industrial researchers. Its main focus is on new developments in genome bioinformatics and computational biology. 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J., 7, 1, 10.2174/1875036201307010001",{"doi":2196},"10.2174/1875036201307010001",{"id":17,"text":2198,"url":17,"identifiers":2199},"Junier, 2010, The Newick utilities: high-throughput phylogenetic tree processing in the Unix shell, Bioinformatics, 26, 1669, 10.1093/bioinformatics/btq243",{"doi":2200},"10.1093/bioinformatics/btq243",{"id":17,"text":2202,"url":17,"identifiers":2203},"Langmead, 2012, Fast gapped-read alignment with Bowtie 2, Nat. Methods, 9, 357, 10.1038/nmeth.1923",{"doi":2204},"10.1038/nmeth.1923",{"id":17,"text":2206,"url":17,"identifiers":2207},"Li, 2009, Fast and accurate short read alignment with Burrows–Wheeler transform, Bioinformatics, 25, 1754, 10.1093/bioinformatics/btp324",{"doi":2208},"10.1093/bioinformatics/btp324",{"id":17,"text":2210,"url":17,"identifiers":2211},"Li, 2010, A survey of sequence alignment algorithms for next-generation sequencing, Brief. Bioinform., 11, 473, 10.1093/bib/bbq015",{"doi":2212},"10.1093/bib/bbq015",{"id":17,"text":2214,"url":17,"identifiers":2215},"Li, 2013, The NGS WikiBook: a dynamic collaborative online training effort with long-term sustainability, Brief. Bioinform., 14, 548, 10.1093/bib/bbt045",{"doi":2216},"10.1093/bib/bbt045",{"id":17,"text":2218,"url":17,"identifiers":2219},"Lindgreen, 2012, AdapterRemoval: easy cleaning of next generation sequencing reads, BMC Res. Notes, 5, 337, 10.1186/1756-0500-5-337",{"doi":2220},"10.1186/1756-0500-5-337",{"id":17,"text":2222,"url":17,"identifiers":2223},"Mardis, 2008, Next-generation DNA sequencing methods, Annu. Rev. Genomics Hum. Genet., 9, 387, 10.1146/annurev.genom.9.081307.164359",{"doi":2224},"10.1146/annurev.genom.9.081307.164359",{"id":17,"text":2226,"url":17,"identifiers":2227},"Martin, 2011, Cutadapt removes adapter sequences from high-throughput sequencing reads, EMBnet. J., 17, 10, 10.14806/ej.17.1.200",{"doi":2228},"10.14806/ej.17.1.200",{"id":17,"text":2230,"url":17,"identifiers":2231},"Zerbino, 2008, Velvet: algorithms for \n de novo\n short read assembly using de Bruijn graphs, Genome Res., 18, 821, 10.1101/gr.074492.107",{"doi":2232},"10.1101/gr.074492.107",{"id":2234,"createTime":2235,"updateTime":2236,"relativeEntities":2237,"slug":2238,"properties":2239,"entityType":205,"verifyStatus":383,"verifyTime":2256,"verifyNote":385,"syncStatus":386,"languages":2257,"translateLanguages":2258,"viewCount":22,"primaryUrl":2259,"fullTextUrl":17,"authors":2260,"publicationType":207,"publisherRelationship":2329,"citationCount":2364,"citationInfo":2365,"publishDate":2380,"publishYear":2381,"citationAnalyzeStatus":386,"lastCitationAnalyze":17,"indexDatabases":17,"openAccess":17,"references":2382,"isForceReanalyzing":24},"6e63d9f8-a110-413d-8d67-c6392088a94f","2024-09-02T10:37:14.539+00:00","2024-12-25T11:06:04.773+00:00",[],"A-consistent-and-accurate-i-ab-initio-i-parametrization-of-density-functional-dispersion-correction-DFT-D-for-the-94-elements-H-Pu",{"mag":2240,"keywords":2242,"openalex":2244,"abstract":2246,"title":2249,"pm":2252,"doi":2254},{"VOID":2241},"2092157292",{"VI":2243},"DFT-D, độ phân tán, tiêu chuẩn Kohn-Sham, số phối hợp phân số, phiếm hàm mật độ, lực nguyên tử, ba thân không cộng tính, hệ thống nguyên tố nhẹ và nặng, tấm graphene, hấp thụ benzene, bề mặt Ag(111)",{"VOID":2245},"W2092157292",{"EN":2247,"VI":2248},"\u003Cjats:p>The method of dispersion correction as an add-on to standard Kohn–Sham density functional theory (DFT-D) has been refined regarding higher accuracy, broader range of applicability, and less empiricism. The main new ingredients are atom-pairwise specific dispersion coefficients and cutoff radii that are both computed from first principles. The coefficients for new eighth-order dispersion terms are computed using established recursion relations. System (geometry) dependent information is used for the first time in a DFT-D type approach by employing the new concept of fractional coordination numbers (CN). They are used to interpolate between dispersion coefficients of atoms in different chemical environments. The method only requires adjustment of two global parameters for each density functional, is asymptotically exact for a gas of weakly interacting neutral atoms, and easily allows the computation of atomic forces. Three-body nonadditivity terms are considered. The method has been assessed on standard benchmark sets for inter- and intramolecular noncovalent interactions with a particular emphasis on a consistent description of light and heavy element systems. The mean absolute deviations for the S22 benchmark set of noncovalent interactions for 11 standard density functionals decrease by 15%–40% compared to the previous (already accurate) DFT-D version. Spectacular improvements are found for a tripeptide-folding model and all tested metallic systems. The rectification of the long-range behavior and the use of more accurate C6 coefficients also lead to a much better description of large (infinite) systems as shown for graphene sheets and the adsorption of benzene on an Ag(111) surface. For graphene it is found that the inclusion of three-body terms substantially (by about 10%) weakens the interlayer binding. We propose the revised DFT-D method as a general tool for the computation of the dispersion energy in molecules and solids of any kind with DFT and related (low-cost) electronic structure methods for large systems.\u003C/jats:p>","\\u003cp\\u003ePhương pháp điều chỉnh độ phân tán như là một bổ sung cho lý thuyết phiếm hàm mật độ Kohn–Sham tiêu chuẩn (DFT-D) đã được tinh chỉnh nhằm đạt độ chính xác cao hơn, phạm vi áp dụng rộng hơn và ít tính kinh nghiệm hơn. Các thành phần mới chủ yếu là các hệ số phân tán cụ thể theo từng cặp nguyên tử và bán kính cắt đều được tính toán từ các nguyên lý đầu tiên. Các hệ số cho các bản số phân tán bậc tám mới được tính thông qua các quan hệ truy hồi đã thiết lập. Thông tin phụ thuộc vào hệ thống (hình học) được sử dụng lần đầu tiên trong phương pháp tiếp cận loại DFT-D bằng việc áp dụng khái niệm mới về số phối hợp phân số (CN). Chúng được dùng để nội suy giữa các hệ số phân tán của các nguyên tử trong các môi trường hóa học khác nhau. Phương pháp chỉ cần điều chỉnh hai tham số toàn cầu cho mỗi phiếm hàm mật độ, có độ chính xác về mặt tiệm cận cho một khí của các nguyên tử trung hòa tương tác yếu và dễ dàng cho phép tính toán các lực nguyên tử. Các hệ số không cộng tính ba thân được xem xét. Phương pháp đã được đánh giá trên các bộ chỉ chuẩn quy tắc cho các tương tác không đồng hóa học bên trong và giữa các phân tử với sự nhấn mạnh đặc biệt vào mô tả nhất quán các hệ thống nguyên tố nhẹ và nặng. Các độ lệch trung bình tuyệt đối cho bộ chỉ chuẩn S22 của các tương tác không hóa trị giảm từ 15% đến 40% so với phiên bản trước (vốn đã chính xác) của DFT-D. Sự cải tiến phi thường được tìm thấy cho một mô hình cuộn gấp tripeptide và tất cả các hệ thống kim loại đã được thử nghiệm. Sự cải chính hành vi tầm xa và việc sử dụng các hệ số C6 chính xác hơn cũng dẫn đến sự mô tả tốt hơn nhiều về các hệ thống lớn (vô hạn) như đã thấy trong các tấm graphene và sự hấp thu của benzene trên bề mặt Ag(111). Đối với graphene, việc bao gồm các hệ số ba thân đã làm yếu đi đáng kể (khoảng 10%) lực liên kết giữa các tầng. Chúng tôi đề xuất phương pháp DFT-D đã được sửa đổi như một công cụ tổng quát cho việc tính toán năng lượng phân tán trong các phân tử và chất rắn thuộc bất kỳ loại nào với DFT và các phương pháp cấu trúc điện tử liên quan (chi phí thấp) cho các hệ thống lớn.\\u003c/p\\u003e",{"EN":2250,"VI":2251},"A consistent and accurate\u003Ci>ab initio\u003C/i>parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu","Một sự tham số hóa nhất quán và chính xác từ \\\\textit{ab initio} của việc điều chỉnh độ phân tán trong lý thuyết phiếm hàm mật độ (DFT-D) cho 94 nguyên tố H-Pu",{"VOID":2253},"20423165",{"VOID":2255},"10.1063/1.3382344","2024-09-02T10:37:14.538+00:00",[388],[390],"https://pubs.aip.org/jcp/article/132/15/154104/926936/A-consistent-and-accurate-ab-initio",[2261,2282,2297,2314],{"id":2262,"sortIndex":22,"researcher":17,"roles":2263,"affiliations":2264,"properties":2275},"48dc5cdb-1883-4677-b3b3-b40ed04e2225",[],[2265],{"id":2266,"sortIndex":22,"affiliation":2267,"properties":17},"f5b79461-9937-4ec9-9352-0c557aeb0077",{"id":2268,"createTime":2269,"updateTime":2269,"relativeEntities":2270,"slug":2271,"properties":2272,"entityType":21,"verifyStatus":386,"verifyTime":17,"verifyNote":17,"syncStatus":386,"languages":17,"translateLanguages":17,"viewCount":22},"cb2fba0c-5015-4252-9bc0-f622d4502ac7","2024-09-02T10:37:14.557+00:00",[],"Universit%C3%A4t-M%C3%BCnster-Theoretische-Organische-Chemie-Organisch-Chemisches-Institut-Corrensstrasse-40-D-48149-M%C3%BCnster-Germany",{"title":2273},{"EN":2274},"Universität Münster Theoretische Organische Chemie, Organisch-Chemisches Institut, , Corrensstrasse 40, D-48149 Münster, Germany",{"openalex":2276,"orcid":2278,"title":2280},{"VOID":2277},"A5042863303",{"VOID":2279},"https://orcid.org/0000-0002-5844-4371",{"EN":2281},"Stefan Grimme",{"id":2283,"sortIndex":58,"researcher":17,"roles":2284,"affiliations":2285,"properties":2292},"6427885b-6126-43a8-9822-634fed702d59",[],[2286],{"id":2287,"sortIndex":22,"affiliation":2288,"properties":17},"dd3b23cb-96b5-4da0-bf04-ad47d7e5c7f1",{"id":2268,"createTime":2269,"updateTime":2269,"relativeEntities":2289,"slug":2271,"properties":2290,"entityType":21,"verifyStatus":386,"verifyTime":17,"verifyNote":17,"syncStatus":386,"languages":17,"translateLanguages":17,"viewCount":22},[],{"title":2291},{"EN":2274},{"openalex":2293,"title":2295},{"VOID":2294},"A5011411945",{"EN":2296},"Helge 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A, 109, 11015, 10.1021/jp053905d",{"doi":2860},"10.1021/jp053905d",{"id":17,"text":2862,"url":17,"identifiers":2863},"2006, J. Phys. Chem. B, 110, 19973, 10.1021/jp062225n",{"doi":2864},"10.1021/jp062225n",{"id":17,"text":2866,"url":17,"identifiers":2867},"2008, Phys. Chem. Chem. Phys., 10, 3327, 10.1039/b803508c",{"doi":2868},"10.1039/b803508c",{"id":2870,"createTime":2871,"updateTime":2872,"relativeEntities":2873,"slug":2874,"properties":2875,"entityType":205,"verifyStatus":383,"verifyTime":2892,"verifyNote":385,"syncStatus":386,"languages":2893,"translateLanguages":2894,"viewCount":22,"primaryUrl":2895,"fullTextUrl":17,"authors":2896,"publicationType":207,"publisherRelationship":2946,"citationCount":2995,"citationInfo":2996,"publishDate":3011,"publishYear":3012,"citationAnalyzeStatus":386,"lastCitationAnalyze":17,"indexDatabases":17,"openAccess":17,"references":3013,"isForceReanalyzing":24},"1a5c18e2-6f43-4571-beee-6193c9966aaf","2024-07-18T21:20:33.086+00:00","2024-12-24T05:30:59.285+00:00",[],"Estimation-of-the-Concentration-of-Low-Density-Lipoprotein-Cholesterol-in-Plasma-Without-Use-of-the-Preparative-Ultracentrifuge",{"mag":2876,"keywords":2878,"openalex":2880,"abstract":2882,"title":2885,"pm":2888,"doi":2890},{"VOID":2877},"2116404316",{"VI":2879},"cholesterol; tổng cholesterol huyết tương; triglyceride; cholesterol lipoprotein mật độ cao; lipoprotein mật độ thấp; phép đo không cần siêu ly tâm; hệ số tương quan; huyết thanh; phương pháp không xâm lấn",{"VOID":2881},"W2116404316",{"EN":2883,"VI":2884},"\u003Cjats:title>Abstract\u003C/jats:title>\n \u003Cjats:p>A method for estimating the cholesterol content of the serum low-density lipoprotein fraction (Sf0-20) is presented. The method involves measurements of fasting plasma total cholesterol, triglyceride, and high-density lipoprotein cholesterol concentrations, none of which requires the use of the preparative ultracentrifuge. Comparison of this suggested procedure with the more direct procedure, in which the ultracentrifuge is used, yielded correlation coefficients of .94 to .99, depending on the patient population compared.\u003C/jats:p>","\u003Cjats:title>Tóm tắt\u003C/jats:title> \u003Cjats:p>Một phương pháp ước tính hàm lượng cholesterol trong phần lipoprotein có tỷ trọng thấp của huyết thanh (Sf0-20) được trình bày. Phương pháp này bao gồm các phép đo nồng độ cholesterol toàn phần trong huyết tương khi đói, triglyceride và cholesterol lipoprotein có tỷ trọng cao, không yêu cầu sử dụng thiết bị siêu ly tâm chuẩn bị. So sánh quy trình được đề xuất này với quy trình trực tiếp hơn, trong đó thiết bị siêu ly tâm được sử dụng, đã cho thấy các hệ số tương quan từ 0,94 đến 0,99, tùy thuộc vào nhóm bệnh nhân được so sánh.\u003C/jats:p>",{"EN":2886,"VI":2887},"Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge","Ước lượng nồng độ cholesterol lipoprotein có tỷ trọng thấp trong huyết tương mà không sử dụng thiết bị siêu ly tâm chuẩn bị",{"VOID":2889},"4337382",{"VOID":2891},"10.1093/clinchem/18.6.499","2024-07-18T21:20:33.085+00:00",[388],[390],"https://academic.oup.com/clinchem/article/18/6/499/5676160",[2897,2916,2931],{"id":2898,"sortIndex":22,"researcher":17,"roles":2899,"affiliations":2900,"properties":2911},"fdfedaab-ffb1-4da6-856e-3c3c8c02a670",[],[2901],{"id":2902,"sortIndex":22,"affiliation":2903,"properties":17},"2485ecee-8eb8-48cf-b68f-5e14d7b0493c",{"id":2904,"createTime":2905,"updateTime":2905,"relativeEntities":2906,"slug":2907,"properties":2908,"entityType":21,"verifyStatus":386,"verifyTime":17,"verifyNote":17,"syncStatus":386,"languages":17,"translateLanguages":17,"viewCount":22},"25001c4b-7fa8-472e-a577-54fdbea6bf32","2024-07-18T21:20:33.095+00:00",[],"Biometrics-Research-Branch-W-T-F-and-the-Molecular-Disease-Branch-R-I-L-and-D-S-F-National-Heart-and-Lung-Institute-9000-Rockville-Pike-Bethesda-Md-20014",{"title":2909},{"EN":2910},"Biometrics Research Branch (W.T.F.) and the Molecular Disease Branch (R.I.L. and D.S.F.), National Heart and Lung Institute, 9000 Rockville Pike, Bethesda, Md. 20014",{"openalex":2912,"title":2914},{"VOID":2913},"A5020575969",{"EN":2915},"William T. Friedewald",{"id":2917,"sortIndex":47,"researcher":17,"roles":2918,"affiliations":2919,"properties":2926},"a9b87cdc-5aaf-46df-8bf6-456a204d4e5a",[],[2920],{"id":2921,"sortIndex":22,"affiliation":2922,"properties":17},"1bac0648-4b2a-4868-82f5-f3fdeac7e311",{"id":2904,"createTime":2905,"updateTime":2905,"relativeEntities":2923,"slug":2907,"properties":2924,"entityType":21,"verifyStatus":386,"verifyTime":17,"verifyNote":17,"syncStatus":386,"languages":17,"translateLanguages":17,"viewCount":22},[],{"title":2925},{"EN":2910},{"openalex":2927,"title":2929},{"VOID":2928},"A5045650765",{"EN":2930},"Donald S. Fredrickson",{"id":2932,"sortIndex":34,"researcher":17,"roles":2933,"affiliations":2934,"properties":2941},"e9aa9242-f6cc-49be-b659-05c70afe533f",[],[2935],{"id":2936,"sortIndex":22,"affiliation":2937,"properties":17},"96acdd44-1b1e-4dd6-8c82-4b02a81d34a5",{"id":2904,"createTime":2905,"updateTime":2905,"relativeEntities":2938,"slug":2907,"properties":2939,"entityType":21,"verifyStatus":386,"verifyTime":17,"verifyNote":17,"syncStatus":386,"languages":17,"translateLanguages":17,"viewCount":22},[],{"title":2940},{"EN":2910},{"openalex":2942,"title":2944},{"VOID":2943},"A5104194836",{"EN":2945},"Robert I. Levy",{"url":17,"publisher":2947,"properties":2989},{"id":2948,"createTime":2949,"updateTime":2950,"relativeEntities":2951,"slug":2952,"properties":2953,"entityType":153,"verifyStatus":386,"verifyTime":17,"verifyNote":17,"syncStatus":386,"languages":17,"translateLanguages":17,"viewCount":22,"subjectFields":2963,"manageAffiliations":2964,"indexDatabases":2965,"url":2988,"thumbnailPath":17,"statistic":17,"gsStatistic":17,"type":17,"analyzePriority":17},"f38c7b65-a001-426c-965b-776400a202e8","2023-05-29T11:23:00.794+00:00","2025-02-11T04:15:09.510+00:00",[],"Clinical-Chemistry",{"country":2954,"issn":2955,"introduce":2957,"eissn":2959,"title":2961},{"VOID":424},{"VOID":2956},"15308561",{"EN":2958},"Clinical Chemistry, issued monthly, is published in print and electronically by the American Association for Clinical Chemistry. The journal welcomes contributions, either experimental or theoretical, in the field of laboratory medicine. It is the leading forum for peer-reviewed, original research on innovative practices in today’s clinical laboratory. In addition to being the most cited journal in the field, Clinical Chemistry has the highest Impact Factor among journals of clinical chemistry, clinical (or anatomic) pathology, analytical chemistry, and the subspecialties, such as transfusion medicine and clinical microbiology.",{"VOID":2960},"00099147",{"EN":2962},"Clinical Chemistry",[],[],[2966,2976],{"id":2967,"indexDatabase":2968,"url":2973,"indexYears":17,"academicFieldIds":2974},"bb347651-9783-47eb-a4d6-7d12f3ac1c80",{"id":459,"createTime":460,"updateTime":461,"relativeEntities":2969,"label":2970,"description":2971,"key":468,"publicationTags":2972,"standard":17},[],{"EN":464,"VI":464},{"VI":466,"EN":467},[470,471],"https://mjl.clarivate.com/search-results?issn=0009-9147",[2975],"5df31f8e-75e1-45c1-bba5-a5fefea76b12",{"id":2977,"indexDatabase":2978,"url":2983,"indexYears":2984,"academicFieldIds":2985},"d9592258-6dda-4cc9-8286-c9bbd4803130",{"id":439,"createTime":440,"updateTime":441,"relativeEntities":2979,"label":2980,"description":2981,"key":447,"publicationTags":2982,"standard":17},[],{"EN":444,"VI":444},{"EN":444,"VI":446},[449],"https://www.scopus.com/sourceid/26786","1955-2023",[2986,454,2987],"c17f7a60-a051-4a17-bc92-1906f5884166","90465d3c-0eac-406f-87d4-6b14482b5ef4","https://academic.oup.com/clinchem",{"volume":2990,"pages":2992,"issue":2994},{"VOID":2991},"18",{"VOID":2993},"499-502",{"VOID":840},29505,{"total":2995,"publishYear":17,"statisticByYear":2997},{"2012":2998,"2013":2999,"2014":3000,"2015":3001,"2016":3002,"2017":3003,"2018":3004,"2019":3005,"2020":3006,"2021":3007,"2022":3008,"2023":3009,"2024":3010},1316,1375,1415,1417,1110,1026,1039,1068,1082,1046,1059,955,405,"1972-06-01",1972,[],{"id":3015,"createTime":3016,"updateTime":3017,"relativeEntities":3018,"slug":3019,"properties":3020,"entityType":205,"verifyStatus":383,"verifyTime":3036,"verifyNote":385,"syncStatus":386,"languages":3037,"translateLanguages":3038,"viewCount":22,"primaryUrl":3039,"fullTextUrl":17,"authors":3040,"publicationType":207,"publisherRelationship":3059,"citationCount":3181,"citationInfo":3182,"publishDate":3197,"publishYear":3198,"citationAnalyzeStatus":386,"lastCitationAnalyze":17,"indexDatabases":17,"openAccess":17,"references":3199,"isForceReanalyzing":24},"64ee1f3b-5ba4-4c30-aa43-91a8bbd0812c","2024-09-03T00:39:26.540+00:00","2024-12-25T11:10:31.233+00:00",[],"Semiempirical-GGA-type-density-functional-constructed-with-a-long-range-dispersion-correction",{"mag":3021,"keywords":3023,"openalex":3025,"abstract":3027,"title":3030,"pm":3033,"doi":3035},{"VOID":3022},"2044591029",{"VI":3024},"Hóa học, Xấp xỉ Gradient Tổng quát, Hàm Mật Độ, Phân Tán, B97‐D",{"VOID":3026},"W2044591029",{"EN":3028,"VI":3029},"\u003Cjats:title>Abstract\u003C/jats:title>\u003Cjats:p>A new density functional (DF) of the generalized gradient approximation (GGA) type for general chemistry applications termed B97‐D is proposed. It is based on Becke's power‐series ansatz from 1997 and is explicitly parameterized by including damped atom‐pairwise dispersion corrections of the form \u003Cjats:italic>C\u003C/jats:italic>\u003Cjats:sub>6\u003C/jats:sub> · \u003Cjats:italic>R\u003C/jats:italic>\u003Cjats:sup>−6\u003C/jats:sup>. A general computational scheme for the parameters used in this correction has been established and parameters for elements up to xenon and a scaling factor for the dispersion part for several common density functionals (BLYP, PBE, TPSS, B3LYP) are reported. The new functional is tested in comparison with other GGAs and the B3LYP hybrid functional on standard thermochemical benchmark sets, for 40 noncovalently bound complexes, including large stacked aromatic molecules and group II element clusters, and for the computation of molecular geometries. Further cross‐validation tests were performed for organometallic reactions and other difficult problems for standard functionals. In summary, it is found that B97‐D belongs to one of the most accurate general purpose GGAs, reaching, for example for the G97/2 set of heat of formations, a mean absolute deviation of only 3.8 kcal mol\u003Cjats:sup>−1\u003C/jats:sup>. The performance for noncovalently bound systems including many pure van der Waals complexes is exceptionally good, reaching on the average CCSD(T) accuracy. The basic strategy in the development to restrict the density functional description to shorter electron correlation lengths scales and to describe situations with medium to large interatomic distances by damped \u003Cjats:italic>C\u003C/jats:italic>\u003Cjats:sub>6\u003C/jats:sub> · \u003Cjats:italic>R\u003C/jats:italic>\u003Cjats:sup>−6\u003C/jats:sup> terms seems to be very successful, as demonstrated for some notoriously difficult reactions. As an example, for the isomerization of larger branched to linear alkanes, B97‐D is the only DF available that yields the right sign for the energy difference. From a practical point of view, the new functional seems to be quite robust and it is thus suggested as an efficient and accurate quantum chemical method for large systems where dispersion forces are of general importance. © 2006 Wiley Periodicals, Inc. J Comput Chem 2006\u003C/jats:p>","\u003Cjats:title>Tóm tắt\u003C/jats:title>\u003Cjats:p>Một hàm mật độ mới (DF) thuộc loại xấp xỉ gradient tổng quát (GGA) cho các ứng dụng hóa học chung có tên là B97‐D được đề xuất. Nó dựa trên phương án chuỗi lũy thừa của Becke từ năm 1997 và được tham số hóa rõ ràng bằng cách bao gồm các hiệu chỉnh phân tán cặp nguyên tử dạng triệt tiêu \u003Cjats:italic>C\u003C/jats:italic>\u003Cjats:sub>6\u003C/jats:sub> · \u003Cjats:italic>R\u003C/jats:italic>\u003Cjats:sup>−6\u003C/jats:sup>. Một sơ đồ tính toán tổng quát cho các tham số được sử dụng trong hiệu chỉnh này đã được thiết lập và các tham số cho các nguyên tố lên tới xenon và một hệ số tỷ lệ cho phần phân tán cho một số hàm mật độ thông thường (BLYP, PBE, TPSS, B3LYP) được báo cáo. Hàm mới được thử nghiệm so sánh với các GGAs khác và hàm lai B3LYP trên các bộ tiêu chuẩn kiểm tra nhiệt hóa học, cho 40 hợp chất liên kết không cộng hóa trị, bao gồm cả các phân tử thơm xếp chồng lớn và cụm nguyên tố nhóm II, và cho việc tính toán hình học phân tử. Thêm vào đó, các bài kiểm tra chéo được thực hiện cho các phản ứng hữu cơ kim loại và các vấn đề khó khăn khác đối với các hàm tiêu chuẩn. Tóm lại, tìm thấy rằng B97‐D thuộc vào một trong những GGAs đa năng chính xác nhất, đạt đến, ví dụ cho bộ G97/2 của nhiệt hình thành, một độ lệch tuyệt đối trung bình chỉ có 3.8 kcal mol\u003Cjats:sup>−1\u003C/jats:sup>. Hiệu suất cho các hệ thống liên kết không cộng hóa trị bao gồm nhiều phức hợp van der Waals thuần rất tốt, đạt đến độ chính xác CCSD(T) trung bình. Chiến lược cơ bản trong phát triển để hạn chế mô tả hàm mật độ đến chiều dài tương quan electron ngắn hơn và mô tả các tình huống với khoảng cách giữa các nguyên tử trung bình đến lớn bằng các thuật ngữ \u003Cjats:italic>C\u003C/jats:italic>\u003Cjats:sub>6\u003C/jats:sub> · \u003Cjats:italic>R\u003C/jats:italic>\u003Cjats:sup>−6\u003C/jats:sup> triệt tiêu dường như rất thành công, như chứng minh cho một số phản ứng khó khăn nổi tiếng. Chẳng hạn, đối với sự đồng phân hóa của các alkan nhánh lớn hơn sang alkan thẳng, B97‐D là hàm duy nhất có sẵn đưa ra dấu đúng cho sự chênh lệch năng lượng. Từ quan điểm thực tế, hàm mới dường như khá chắc chắn và do đó được đề xuất như một phương pháp hóa học lượng tử hiệu quả và chính xác cho các hệ thống lớn nơi lực phân tán có tầm quan trọng chung. © 2006 Wiley Periodicals, Inc. J Comput Chem 2006\u003C/jats:p>",{"EN":3031,"VI":3032},"Semiempirical GGA‐type density functional constructed with a long‐range dispersion correction","Chức năng mật độ loại GGA bán thực nghiệm được xây dựng với sự hiệu chỉnh phân tán tầm xa",{"VOID":3034},"16955487",{"VOID":2519},"2024-09-03T00:39:26.539+00:00",[388],[390],"https://onlinelibrary.wiley.com/doi/10.1002/jcc.20495",[3041],{"id":3042,"sortIndex":22,"researcher":17,"roles":3043,"affiliations":3044,"properties":3055},"977eb514-3752-43d3-8618-8c5bbfb296ce",[],[3045],{"id":3046,"sortIndex":22,"affiliation":3047,"properties":17},"b17488e5-1a8c-481f-a99c-86810761975d",{"id":3048,"createTime":3049,"updateTime":3049,"relativeEntities":3050,"slug":3051,"properties":3052,"entityType":21,"verifyStatus":386,"verifyTime":17,"verifyNote":17,"syncStatus":386,"languages":17,"translateLanguages":17,"viewCount":22},"ab1d2f8b-7f24-4583-b0d0-cd3cee420ec2","2024-09-03T00:39:26.579+00:00",[],"Theoretische-Organische-Chemie-Organisch-Chemisches-Institut-der-Universit%C3%A4t-M%C3%BCnster-Corrensstra%C3%9Fe-40-D-48149-M%C3%BCnster-Germany",{"title":3053},{"EN":3054},"Theoretische Organische Chemie, Organisch‐Chemisches Institut der Universität Münster, Corrensstraße 40, D‐48149 Münster, Germany",{"openalex":3056,"orcid":3057,"title":3058},{"VOID":2277},{"VOID":2279},{"EN":2281},{"url":17,"publisher":3060,"properties":3175},{"id":3061,"createTime":3062,"updateTime":3063,"relativeEntities":3064,"slug":3065,"properties":3066,"entityType":153,"verifyStatus":386,"verifyTime":17,"verifyNote":17,"syncStatus":386,"languages":17,"translateLanguages":17,"viewCount":22,"subjectFields":3076,"manageAffiliations":3077,"indexDatabases":3078,"url":3100,"thumbnailPath":17,"statistic":3101,"gsStatistic":17,"type":17,"analyzePriority":17},"5350c404-9447-4908-a117-26d35d12145a","2023-05-29T10:33:13.043+00:00","2025-02-08T17:26:25.500+00:00",[],"Journal-of-Computational-Chemistry",{"country":3067,"issn":3068,"introduce":3070,"eissn":3072,"title":3074},{"VOID":424},{"VOID":3069},"1096987X",{"EN":3071},"This distinguished journal publishes articles concerned with all aspects of computational chemistry: analytical, biological, inorganic, organic, physical, and materials. The Journal of Computational Chemistry presents original research, contemporary developments in theory and methodology, and state-of-the-art applications. 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The program displays electron-density maps and atomic models and allows model manipulations such as idealization, real-space refinement, manual rotation/translation, rigid-body fitting, ligand search, solvation, mutations, rotamers and Ramachandran idealization. Furthermore, tools are provided for model validation as well as interfaces to external programs for refinement, validation and graphics. The software is designed to be easy to learn for novice users, which is achieved by ensuring that tools for common tasks are `discoverable' through familiar user-interface elements (menus and toolbars) or by intuitive behaviour (mouse controls). Recent developments have focused on providing tools for expert users, with customisable key bindings, extensions and an extensive scripting interface. The software is under rapid development, but has already achieved very widespread use within the crystallographic community. The current state of the software is presented, with a description of the facilities available and of some of the underlying methods employed.\u003C/jats:p>","\u003Cjats:p> \u003Cjats:italic>Coot\u003C/jats:italic> là một ứng dụng đồ họa phân tử chuyên dùng cho việc xây dựng và thẩm định mô hình phân tử sinh học vĩ mô. Chương trình hiển thị các bản đồ mật độ điện tử và các mô hình nguyên tử, đồng thời cho phép thực hiện các thao tác mô hình như chuẩn hóa, tinh chỉnh không gian thực, xoay/chuyển tay chân, hiệu chỉnh khối cố định, tìm kiếm phối tử, hydrat hóa, đột biến, phối hợp và chuẩn hóa Ramachandran. Hơn nữa, các công cụ cũng được cung cấp để thẩm định mô hình cũng như giao diện với các chương trình bên ngoài để tinh chỉnh, thẩm định và đồ họa. Phần mềm được thiết kế để dễ dàng học hỏi cho người dùng mới, nhờ vào việc đảm bảo rằng các công cụ cho những tác vụ thông thường có thể được phát hiện thông qua các thành phần giao diện người dùng quen thuộc (menu và thanh công cụ) hoặc bởi hành vi trực quan (điều khiển bằng chuột). Những phát triển gần đây đã tập trung vào việc cung cấp các công cụ cho người dùng chuyên nghiệp, với các phím tắt có thể tùy chỉnh, mở rộng và một giao diện kịch bản phong phú. Phần mềm đang trong giai đoạn phát triển nhanh chóng, nhưng đã đã đạt được sự phổ biến rộng rãi trong cộng đồng tinh thể học. Tình trạng hiện tại của phần mềm được trình bày, cùng với mô tả các tiện ích có sẵn và một số phương pháp cơ bản được sử dụng.\u003C/jats:p>",{"EN":3424,"VI":3425},"Features and development of \u003Ci>Coot\u003C/i>","Đặc điểm và sự phát triển của \u003Ci>Coot\u003C/i>",{"VOID":3427},"20383002",{"VOID":3429},"10.1107/s0907444910007493","2024-08-31T15:33:32.585+00:00",[388],[390],"https://scripts.iucr.org/cgi-bin/paper?S0907444910007493",[3435,3457,3478,3499],{"id":3436,"sortIndex":22,"researcher":17,"roles":3437,"affiliations":3438,"properties":3450},"153965db-00a4-4c45-b0f8-38500033fe7f",[],[3439],{"id":3440,"sortIndex":22,"affiliation":3441,"properties":17},"393269e4-485d-4896-9f7e-3b6b9040fa3a",{"id":3442,"createTime":3443,"updateTime":3444,"relativeEntities":3445,"slug":3446,"properties":3447,"entityType":21,"verifyStatus":386,"verifyTime":17,"verifyNote":17,"syncStatus":386,"languages":17,"translateLanguages":17,"viewCount":22},"63e46f94-3965-425c-8c10-14aba7980abb","2024-01-15T04:26:57.152+00:00","2024-09-18T11:26:38.613+00:00",[],"Department-of-Biochemistry-University-of-Oxford-South-Parks-Road-Oxford-OX1-3QU-England",{"title":3448},{"VI":3449},"Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, England",{"openalex":3451,"orcid":3453,"title":3455},{"VOID":3452},"A5071138931",{"VOID":3454},"https://orcid.org/0000-0002-0138-5227",{"EN":3456},"Paul Emsley",{"id":3458,"sortIndex":58,"researcher":17,"roles":3459,"affiliations":3460,"properties":3471},"7e0f97a0-63e6-4b9f-ae20-d82eb43c5f58",[],[3461],{"id":3462,"sortIndex":22,"affiliation":3463,"properties":17},"ed8d0669-ee26-4924-b86e-91c733d866f1",{"id":3464,"createTime":3465,"updateTime":3465,"relativeEntities":3466,"slug":3467,"properties":3468,"entityType":21,"verifyStatus":386,"verifyTime":17,"verifyNote":17,"syncStatus":386,"languages":17,"translateLanguages":17,"viewCount":22},"44ad9332-49a7-43a0-8c10-e960266bce2d","2024-08-31T15:33:32.630+00:00",[],"Department-of-Chemistry-University-of-York-Heslington-YORK-YO10-5DD-England",{"title":3469},{"EN":3470},"Department of Chemistry, University of York, Heslington, YORK, YO10 5DD, England",{"openalex":3472,"orcid":3474,"title":3476},{"VOID":3473},"A5018808577",{"VOID":3475},"https://orcid.org/0000-0002-0189-1437",{"EN":3477},"Kevin Cowtan",{"id":3479,"sortIndex":47,"researcher":17,"roles":3480,"affiliations":3481,"properties":3492},"1048c07e-ae12-4101-9d98-50bf6fc092f2",[],[3482],{"id":3483,"sortIndex":22,"affiliation":3484,"properties":17},"8e3e3a43-13aa-4051-ace8-cc901bde84bf",{"id":3485,"createTime":3486,"updateTime":3486,"relativeEntities":3487,"slug":3488,"properties":3489,"entityType":21,"verifyStatus":386,"verifyTime":17,"verifyNote":17,"syncStatus":386,"languages":17,"translateLanguages":17,"viewCount":22},"c76f8fca-7489-430e-92e0-8f0f48896ded","2024-08-31T15:33:32.617+00:00",[],"Department-of-Chemistry-University-of-California-1156-High-Street-Santa-Cruz-CA-95064-USA",{"title":3490},{"EN":3491},"Department of Chemistry, University of California, 1156 High Street, Santa Cruz, CA 95064, USA",{"openalex":3493,"orcid":3495,"title":3497},{"VOID":3494},"A5063283743",{"VOID":3496},"https://orcid.org/0000-0002-9273-3564",{"EN":3498},"W. G. Scott",{"id":3500,"sortIndex":34,"researcher":17,"roles":3501,"affiliations":3502,"properties":3514},"b56e4a72-ddd7-4022-ad53-04b4e76ac7f7",[],[3503],{"id":3504,"sortIndex":22,"affiliation":3505,"properties":17},"9e5bb95a-6cca-4252-bf19-dc6659f308c0",{"id":3506,"createTime":3507,"updateTime":3508,"relativeEntities":3509,"slug":3510,"properties":3511,"entityType":21,"verifyStatus":386,"verifyTime":17,"verifyNote":17,"syncStatus":386,"languages":17,"translateLanguages":17,"viewCount":22},"113b5341-7968-4244-b77e-f3ecf0618272","2023-12-22T01:20:02.487+00:00","2024-08-31T15:33:32.607+00:00",[],"Department-of-Medical-Biochemistry-and-Biophysics-Karolinska-Institute-SE-171-77-Stockholm-Sweden",{"title":3512},{"VI":3513},"Department of Medical Biochemistry and Biophysics, Karolinska Institute, SE-171 77 Stockholm, Sweden",{"openalex":3515,"orcid":3517,"title":3519},{"VOID":3516},"A5073942998",{"VOID":3518},"https://orcid.org/0000-0002-5646-2090",{"EN":3520},"Bernhard Lohkamp",{"url":17,"publisher":3522,"properties":3536},{"id":3523,"createTime":3524,"updateTime":3525,"relativeEntities":3526,"slug":3527,"properties":3528,"entityType":153,"verifyStatus":386,"verifyTime":17,"verifyNote":17,"syncStatus":386,"languages":17,"translateLanguages":17,"viewCount":22,"subjectFields":3533,"manageAffiliations":3534,"indexDatabases":3535,"url":17,"thumbnailPath":17,"statistic":17,"gsStatistic":17,"type":17,"analyzePriority":17},"d6dff9c0-8eb4-4ff9-9c9c-ae1119253d3d","2024-08-31T13:29:01.078+00:00","2025-02-10T15:50:22.197+00:00",[],"International-Union-of-Crystallography-IUCr-",{"issn":3529,"title":3531},{"VOID":3530},"0907-4449",{"EN":3532},"International Union of Crystallography (IUCr)",[],[],[],{"volume":3537,"pages":3539,"issue":3541},{"VOID":3538},"66",{"VOID":3540},"486-501",{"VOID":3542},"4",24375,{"total":3543,"publishYear":17,"statisticByYear":3545},{"2012":3546,"2013":812,"2014":3547,"2015":3548,"2016":3549,"2017":3550,"2018":3551,"2019":3552,"2020":3553,"2021":3554,"2022":3555,"2023":3556,"2024":3557},674,1076,1337,1485,1654,1949,2291,2623,2552,2632,2607,1497,"2010-04-01",[3560,3564,3568,3572,3576,3579,3583,3586,3590,3594,3598,3602,3605,3609,3613,3617,3621,3625,3629,3633,3637,3641,3644,3648,3652,3656,3660,3663,3667,3671,3675,3679,3683,3687,3690,3694,3698,3702,3706,3710,3714,3717,3721,3725,3729,3733,3737],{"id":17,"text":3561,"url":17,"identifiers":3562},"Adams, 2002, Acta Cryst. 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Biol., 9, 371, 10.1016/j.cbpa.2005.06.007",{"doi":3728},"10.1016/j.cbpa.2005.06.007",{"id":17,"text":3730,"url":17,"identifiers":3731},"Word, 1999, J. Mol. Biol., 285, 1711, 10.1006/jmbi.1998.2400",{"doi":3732},"10.1006/jmbi.1998.2400",{"id":17,"text":3734,"url":17,"identifiers":3735},"Word, 1999, J. Mol. Biol., 285, 1735, 10.1006/jmbi.1998.2401",{"doi":3736},"10.1006/jmbi.1998.2401",{"id":17,"text":3738,"url":17,"identifiers":3739},"Zhang, 1997, Methods Enzymol., 277, 53, 10.1016/S0076-6879(97)77006-X",{"doi":3740},"10.1016/S0076-6879(97)77006-X",{"id":3742,"createTime":3743,"updateTime":3744,"relativeEntities":3745,"slug":3746,"properties":3747,"entityType":205,"verifyStatus":383,"verifyTime":3743,"verifyNote":385,"syncStatus":386,"languages":3763,"translateLanguages":3764,"viewCount":22,"primaryUrl":3765,"fullTextUrl":17,"authors":3766,"publicationType":207,"publisherRelationship":3810,"citationCount":3879,"citationInfo":3880,"publishDate":3894,"publishYear":3895,"citationAnalyzeStatus":386,"lastCitationAnalyze":17,"indexDatabases":17,"openAccess":17,"references":3896,"isForceReanalyzing":24},"9857ce07-33ee-4cd5-a111-02c5ce38bab0","2024-09-01T10:25:34.499+00:00","2024-12-28T08:45:44.130+00:00",[],"-b-Floral-dip-a-simplified-method-for-b-i-b-Agrobacterium-b-i-b-mediated-transformation-of-b-i-b-Arabidopsis-thaliana-b-i-",{"mag":3748,"keywords":3750,"openalex":3751,"abstract":3753,"title":3756,"pm":3759,"doi":3761},{"VOID":3749},"2116122104",{"VI":15},{"VOID":3752},"W2116122104",{"EN":3754,"VI":3755},"\u003Cjats:title>Summary\u003C/jats:title>\u003Cjats:p> \u003Cjats:bold>The\u003C/jats:bold>\n \u003Cjats:italic>\n \u003Cjats:bold>Agrobacterium\u003C/jats:bold>\n \u003C/jats:italic>\n \u003Cjats:bold>vacuum infiltration method has made it possible to transform\u003C/jats:bold>\n \u003Cjats:italic>\n \u003Cjats:bold>Arabidopsis thaliana\u003C/jats:bold>\n \u003C/jats:italic>\n \u003Cjats:bold>without plant tissue culture or regeneration. In the present study, this method was evaluated and a substantially modified transformation method was developed. The labor‐intensive vacuum infiltration process was eliminated in favor of simple dipping of developing floral tissues into a solution containing\u003C/jats:bold>\n \u003Cjats:italic>\n \u003Cjats:bold>Agrobacterium tumefaciens\u003C/jats:bold>\n \u003C/jats:italic>\n \u003Cjats:bold>, 5% sucrose and 500 microliters per litre of surfactant Silwet L‐77. Sucrose and surfactant were critical to the success of the floral dip method. Plants inoculated when numerous immature floral buds and few siliques were present produced transformed progeny at the highest rate. Plant tissue culture media, the hormone benzylamino purine and pH adjustment were unnecessary, and\u003C/jats:bold>\n \u003Cjats:italic>\n \u003Cjats:bold>Agrobacterium\u003C/jats:bold>\n \u003C/jats:italic>\n \u003Cjats:bold>could be applied to plants at a range of cell densities. Repeated application of\u003C/jats:bold>\n \u003Cjats:italic>\n \u003Cjats:bold>Agrobacterium\u003C/jats:bold>\n \u003C/jats:italic>\n \u003Cjats:bold>improved transformation rates and overall yield of transformants approximately twofold. Covering plants for 1 day to retain humidity after inoculation also raised transformation rates twofold. Multiple ecotypes were transformable by this method. The modified method should facilitate high‐throughput transformation of\u003C/jats:bold>\n \u003Cjats:italic>\n \u003Cjats:bold>Arabidopsis\u003C/jats:bold>\n \u003C/jats:italic>\n \u003Cjats:bold>for efforts such as T‐DNA gene tagging, positional cloning, or attempts at targeted gene replacement.\u003C/jats:bold> \u003C/jats:p>","\u003Cjats:title>Tóm tắt\u003C/jats:title>\u003Cjats:p> \u003Cjats:bold>Phương pháp\u003C/jats:bold>\n \u003Cjats:italic>\n \u003Cjats:bold>Agrobacterium\u003C/jats:bold>\n \u003C/jats:italic>\n \u003Cjats:bold>nhúng chân không đã tạo điều kiện để biến đổi\u003C/jats:bold>\n \u003Cjats:italic>\n \u003Cjats:bold>Arabidopsis thaliana\u003C/jats:bold>\n \u003C/jats:italic>\n \u003Cjats:bold>mà không cần nuôi cấy mô thực vật hoặc tái sinh. Trong nghiên cứu hiện tại, phương pháp này đã được đánh giá và một phương pháp biến đổi đã được cải tiến đáng kể. Quá trình nhúng chân không tốn sức lao động đã được loại bỏ để thay thế bằng việc nhúng các mô hoa đang phát triển vào dung dịch chứa\u003C/jats:bold>\n \u003Cjats:italic>\n \u003Cjats:bold>Agrobacterium tumefaciens\u003C/jats:bold>\n \u003C/jats:italic>\n \u003Cjats:bold>, 5% sucrose và 500 microlit trên lít chất hoạt động bề mặt Silwet L-77. Sucrose và chất hoạt động bề mặt là yếu tố quan trọng cho sự thành công của phương pháp nhúng hoa. Cây trồng được tiêm nhiễm khi có nhiều chồi hoa non và ít quả đã cho ra thế hệ biến đổi với tỷ lệ cao nhất. Môi trường nuôi cấy mô thực vật, hormone benzylaminopurine và điều chỉnh pH không cần thiết, và\u003C/jats:bold>\n \u003Cjats:italic>\n \u003Cjats:bold>Agrobacterium\u003C/jats:bold>\n \u003C/jats:italic>\n \u003Cjats:bold>có thể được áp dụng cho cây trồng với nhiều mật độ tế bào khác nhau. Việc lặp lại việc áp dụng\u003C/jats:bold>\n \u003Cjats:italic>\n \u003Cjats:bold>Agrobacterium\u003C/jats:bold>\n \u003C/jats:italic>\n \u003Cjats:bold>đã cải thiện tỷ lệ biến đổi và tổng năng suất cây biến đổi lên khoảng gấp đôi. Che phủ cây trồng trong 1 ngày để giữ độ ẩm sau khi tiêm nhiễm cũng làm tăng tỷ lệ biến đổi gấp đôi. Nhiều loại sinh thái khác nhau có thể được biến đổi bằng phương pháp này. Phương pháp đã được cải tiến này sẽ tạo điều kiện cho sự biến đổi cao qua việc hỗ trợ cho các nỗ lực như đánh dấu gen T-DNA, cloning vị trí, hoặc các nỗ lực thay thế gen mục tiêu.\u003C/jats:bold> \u003C/jats:p>",{"EN":3757,"VI":3758},"\u003Cb>Floral dip: a simplified method for\u003C/b>\u003Ci>\u003Cb>Agrobacterium\u003C/b>\u003C/i>\u003Cb>‐mediated transformation of\u003C/b>\u003Ci>\u003Cb>Arabidopsis thaliana\u003C/b>\u003C/i>","\u003Cb>Nhúng hoa: một phương pháp đơn giản hóa cho\u003C/b>\u003Ci>\u003Cb>Agrobacterium\u003C/b>\u003C/i>\u003Cb>-trung gian biến đổi\u003C/b>\u003Ci>\u003Cb>Arabidopsis thaliana\u003C/b>\u003C/i>",{"VOID":3760},"10069079",{"VOID":3762},"10.1046/j.1365-313x.1998.00343.x",[388],[390],"https://onlinelibrary.wiley.com/doi/10.1046/j.1365-313x.1998.00343.x",[3767,3789],{"id":3768,"sortIndex":34,"researcher":17,"roles":3769,"affiliations":3770,"properties":3782},"c0114011-3ca2-4938-818d-9509410e2545",[],[3771],{"id":3772,"sortIndex":22,"affiliation":3773,"properties":17},"c7645e5d-0fa1-49d3-b8a3-192828a8de9c",{"id":3774,"createTime":3775,"updateTime":3776,"relativeEntities":3777,"slug":3778,"properties":3779,"entityType":21,"verifyStatus":386,"verifyTime":17,"verifyNote":17,"syncStatus":386,"languages":17,"translateLanguages":17,"viewCount":22},"ac38a790-5aeb-47b2-84df-b6e99dd64e5e","2023-12-11T23:12:01.781+00:00","2024-09-01T10:25:34.579+00:00",[],"Department-of-Crop-Sciences-University-of-Illinois-at-Urbana-Champaign-1201-W-Gregory-Dr-Urbana-IL-61801-USA",{"title":3780},{"VI":3781},"Department of Crop Sciences, University of Illinois at Urbana-Champaign, 1201 W Gregory Dr., Urbana, IL, 61801, USA",{"openalex":3783,"orcid":3785,"title":3787},{"VOID":3784},"A5020822578",{"VOID":3786},"https://orcid.org/0000-0001-6610-9525",{"EN":3788},"Andrew F. Bent",{"id":3790,"sortIndex":22,"researcher":17,"roles":3791,"affiliations":3792,"properties":3803},"5ad2b9e8-2902-4847-9fc0-005398481a66",[],[3793],{"id":3794,"sortIndex":22,"affiliation":3795,"properties":17},"3c41bd25-6037-4f80-ab85-8c23179cfdc2",{"id":3796,"createTime":3797,"updateTime":3797,"relativeEntities":3798,"slug":3799,"properties":3800,"entityType":21,"verifyStatus":386,"verifyTime":17,"verifyNote":17,"syncStatus":386,"languages":17,"translateLanguages":17,"viewCount":22},"9e66d03d-c407-4dc0-9ed2-8bc9946eb423","2024-09-01T10:25:34.520+00:00",[],"Department-of-Crop-Sciences-University-of-Illinois-at-Urbana-Champaign-61801-USA-",{"title":3801},{"EN":3802},"Department of Crop Sciences, University of Illinois at Urbana-Champaign, 61801, USA.",{"openalex":3804,"orcid":3806,"title":3808},{"VOID":3805},"A5038539249",{"VOID":3807},"https://orcid.org/0000-0002-4156-3833",{"EN":3809},"Steven J. Clough",{"url":17,"publisher":3811,"properties":3873},{"id":3812,"createTime":3813,"updateTime":3814,"relativeEntities":3815,"slug":3816,"properties":3817,"entityType":153,"verifyStatus":386,"verifyTime":17,"verifyNote":17,"syncStatus":386,"languages":17,"translateLanguages":17,"viewCount":22,"subjectFields":3827,"manageAffiliations":3828,"indexDatabases":3829,"url":3853,"thumbnailPath":17,"statistic":3854,"gsStatistic":17,"type":17,"analyzePriority":17},"a0983d47-9c8a-45ed-bec7-2b7741924093","2023-05-29T11:07:34.054+00:00","2025-02-11T04:17:03.280+00:00",[],"Plant-Journal",{"country":3818,"issn":3819,"introduce":3821,"eissn":3823,"title":3825},{"VOID":2058},{"VOID":3820},"1365313X",{"EN":3822},"Publishing the best original research papers in all key areas of modern plant biology from the world\"s leading laboratories, The Plant Journal provides a dynamic forum for this ever growing international research community. Plant science research is now at the forefront of research in the biological sciences, with breakthroughs in our understanding of fundamental processes in plants matching those in other organisms. The impact of molecular genetics and the availability of model and crop species can be seen in all aspects of plant biology. For publication in The Plant Journal the research must provide a highly significant new contribution to our understanding of plants and be of general interest to the plant science community.",{"VOID":3824},"09607412",{"EN":3826},"Plant Journal",[],[],[3830,3843],{"id":3831,"indexDatabase":3832,"url":3837,"indexYears":3838,"academicFieldIds":3839},"c1283282-e159-463e-867b-582a155f1f87",{"id":439,"createTime":440,"updateTime":441,"relativeEntities":3833,"label":3834,"description":3835,"key":447,"publicationTags":3836,"standard":17},[],{"EN":444,"VI":444},{"EN":444,"VI":446},[449],"https://www.scopus.com/sourceid/16612","1991-2023",[3840,3841,3842],"0a123226-342a-4226-9f31-dbd65f4aaf4b","8d793241-fb62-4735-9243-df74a7813046","d2139bd1-2fdb-481b-a416-9c30dd0cc173",{"id":3844,"indexDatabase":3845,"url":3850,"indexYears":17,"academicFieldIds":3851},"1d81e8c6-fc89-4066-b777-d6a361636298",{"id":459,"createTime":460,"updateTime":461,"relativeEntities":3846,"label":3847,"description":3848,"key":468,"publicationTags":3849,"standard":17},[],{"EN":464,"VI":464},{"VI":466,"EN":467},[470,471],"https://mjl.clarivate.com/search-results?issn=0960-7412",[3852],"358d4f60-a926-4ec8-965c-590255430c86","https://onlinelibrary.wiley.com/journal/1365313x",{"impactFactor":22,"impactFactorByYear":3855,"i10Index":488,"i10IndexLast5Year":705,"totalPublication":488,"totalPublicationByYear":3859,"totalCitation":3860,"totalCitationByYear":3861,"totalCitationPerPublication":3868,"totalCitationPerPublicationByYear":3869,"hindexLast5Year":488,"hindex":488},{"2015":3856,"2016":3857,"2020":2113,"2021":796,"2022":809,"2023":3858},1.29,2.14,49,{"2002":34,"2008":34,"2009":34,"2014":2113,"2019":58,"2021":47},1299,{"2002":3862,"2008":3863,"2009":3864,"2014":3865,"2019":3866,"2021":3867},128,234,224,338,123,184,81.19,{"2002":3862,"2008":3863,"2009":3864,"2014":3870,"2019":3871,"2021":3872},48.29,41,92,{"volume":3874,"pages":3876,"issue":3878},{"VOID":3875},"16",{"VOID":3877},"735-743",{"VOID":840},19831,{"total":3879,"publishYear":17,"statisticByYear":3881},{"2012":3882,"2013":3883,"2014":3884,"2015":3885,"2016":3886,"2017":3004,"2018":3887,"2019":3888,"2020":3889,"2021":3890,"2022":3891,"2023":3892,"2024":3893},836,954,993,913,937,1058,1176,1245,1253,1364,1231,750,"1998-12-01",1998,[3897,3900,3903,3906,3909,3912,3915,3918,3921,3924,3927,3930,3933,3936,3939,3942,3945,3948,3951,3954,3957,3960,3963,3966,3969,3972,3975,3978,3981,3984],{"id":17,"text":3898,"url":17,"identifiers":3899},"Ausubel F.M., 1997, Current Protocols in Molecular Biology",{},{"id":17,"text":3901,"url":17,"identifiers":3902},"10.1016/S0168-9525(97)01094-9",{"doi":3901},{"id":17,"text":3904,"url":17,"identifiers":3905},"Bechtold N., 1993, In planta Agrobacterium mediated gene transfer by infiltration of adult Arabidopsis thaliana plants., C. R. Acad. Sci. Paris, Life Sciences, 316, 1194",{},{"id":17,"text":3907,"url":17,"identifiers":3908},"Bent A.F., 1998, Plant Molecular Biology Manual, 1",{},{"id":17,"text":3910,"url":17,"identifiers":3911},"10.1126/science.8091210",{"doi":3910},{"id":17,"text":3913,"url":17,"identifiers":3914},"Bouchez D., 1993, A binary vector based on basta resistance for in planta transformation of, Arabidopsis Thaliana. C. R. Acad. Sci. Paris, Life Sciences, 316, 1188",{},{"id":17,"text":3916,"url":17,"identifiers":3917},"10.1046/j.1365-313X.1994.5040551.x",{"doi":3916},{"id":17,"text":3919,"url":17,"identifiers":3920},"10.1016/S1360-1385(96)10047-9",{"doi":3919},{"id":17,"text":3922,"url":17,"identifiers":3923},"10.1142/9789814439701_0010",{"doi":3922},{"id":17,"text":3925,"url":17,"identifiers":3926},"10.1007/BF00330414",{"doi":3925},{"id":17,"text":3928,"url":17,"identifiers":3929},"10.1007/BF00297277",{"doi":3928},{"id":17,"text":3931,"url":17,"identifiers":3932},"10.1073/pnas.94.6.2122",{"doi":3931},{"id":17,"text":3934,"url":17,"identifiers":3935},"10.1126/science.280.5365.918",{"doi":3934},{"id":17,"text":3937,"url":17,"identifiers":3938},"10.1007/BF01977351",{"doi":3937},{"id":17,"text":3940,"url":17,"identifiers":3941},"10.1007/BF00015604",{"doi":3940},{"id":17,"text":3943,"url":17,"identifiers":3944},"10.1007/BF00290117",{"doi":3943},{"id":17,"text":3946,"url":17,"identifiers":3947},"10.1073/pnas.86.21.8467",{"doi":3946},{"id":17,"text":3949,"url":17,"identifiers":3950},"10.1007/BF00331014",{"doi":3949},{"id":17,"text":3952,"url":17,"identifiers":3953},"10.1105/tpc.5.8.865",{"doi":3952},{"id":17,"text":3955,"url":17,"identifiers":3956},"10.1007/BF00028894",{"doi":3955},{"id":17,"text":3958,"url":17,"identifiers":3959},"10.1128/jb.174.4.1189-1196.1992",{"doi":3958},{"id":17,"text":3961,"url":17,"identifiers":3962},"Mollier P., 1995, Promoterless gusA expression in a large number of Arabidopsis thaliana transformants obtained by the in planta infiltration method., C. R. Acad. Sci. Paris, Life Sciences, 318, 465",{},{"id":17,"text":3964,"url":17,"identifiers":3965},"10.1105/tpc.9.3.317",{"doi":3964},{"id":17,"text":3967,"url":17,"identifiers":3968},"10.1007/BF00027558",{"doi":3967},{"id":17,"text":3970,"url":17,"identifiers":3971},"10.1071/PP97109",{"doi":3970},{"id":17,"text":3973,"url":17,"identifiers":3974},"Siemens J., 1996, Transgenic plants: genetic transformation – recent developments and state of the art., Plant Tissue Culture and Biotech., 2, 66",{},{"id":17,"text":3976,"url":17,"identifiers":3977},"10.1073/pnas.85.15.5536",{"doi":3976},{"id":17,"text":3979,"url":17,"identifiers":3980},"10.1146/annurev.ge.22.120188.002225",{"doi":3979},{"id":17,"text":3982,"url":17,"identifiers":3983},"Whalen M., 1991, Identification of Pseudomonas syringae pathogens of Arabidopsis thaliana and a bacterial gene determining avirulence on both Arabidopsis and soybean., Plant Cell, 3, 49",{},{"id":17,"text":3985,"url":17,"identifiers":3986},"Winans S.C., 1992, Two‐way chemical signaling in Agrobacterium–plant interactions., Microbiol. Rev., 56, 12, 10.1128/mr.56.1.12-31.1992",{"doi":3987},"10.1128/mr.56.1.12-31.1992",{"id":3989,"createTime":3990,"updateTime":3991,"relativeEntities":3992,"slug":3993,"properties":3994,"entityType":205,"verifyStatus":386,"verifyTime":3990,"verifyNote":4009,"syncStatus":386,"languages":4010,"translateLanguages":4011,"viewCount":22,"primaryUrl":4012,"fullTextUrl":17,"authors":4013,"publicationType":207,"publisherRelationship":4041,"citationCount":4122,"citationInfo":4123,"publishDate":4137,"publishYear":4138,"citationAnalyzeStatus":386,"lastCitationAnalyze":17,"indexDatabases":17,"openAccess":17,"references":4139,"isForceReanalyzing":24},"9e730456-b52c-4a6b-ba67-9155ce6b57e6","2024-07-19T11:53:36.739+00:00","2024-12-24T20:30:24.187+00:00",[],"Accurate-spin-dependent-electron-liquid-correlation-energies-for-local-spin-density-calculations-a-critical-analysis",{"mag":3995,"keywords":3997,"openalex":3999,"abstract":4001,"title":4004,"doi":4007},{"VOID":3996},"2038533471",{"VI":3998},"khí điện tử đồng nhất, phân cực spin, xấp xỉ mật độ spin địa phương, năng lượng tương quan, nội suy Padé, Ceperley và Alder, tương quan RPA, từ tính, hiệu chỉnh không địa phương",{"VOID":4000},"W2038533471",{"EN":4002,"VI":4003},"\u003Cjats:p> We assess various approximate forms for the correlation energy per particle of the spin-polarized homogeneous electron gas that have frequently been used in applications of the local spin density approximation to the exchange-correlation energy functional. By accurately recalculating the RPA correlation energy as a function of electron density and spin polarization we demonstrate the inadequacies of the usual approximation for interpolating between the para- and ferro-magnetic states and present an accurate new interpolation formula. A Padé approximant technique is used to accurately interpolate the recent Monte Carlo results (para and ferro) of Ceperley and Alder into the important range of densities for atoms, molecules, and metals. These results can be combined with the RPA spin-dependence so as to produce a correlation energy for a spin-polarized homogeneous electron gas with an estimated maximum error of 1 mRy and thus should reliably determine the magnitude of non-local corrections to the local spin density approximation in real systems. \u003C/jats:p>","\u003Cjats:p>Chúng tôi đánh giá các hình thức gần đúng khác nhau cho năng lượng tương quan trên mỗi phần tử của khí điện tử đồng nhất có phân cực spin, những hình thức này đã được sử dụng thường xuyên trong các ứng dụng của xấp xỉ mật độ spin địa phương vào chức năng năng lượng trao đổi-tương quan. Bằng cách tính toán lại chính xác năng lượng tương quan RPA như là một hàm của mật độ điện tử và phân cực spin, chúng tôi chứng minh sự không đầy đủ của các xấp xỉ thông thường trong việc nội suy giữa các trạng thái para-magnet và ferro-magnet, đồng thời giới thiệu một công thức nội suy mới chính xác. Một kỹ thuật xấp xỉ Padé được sử dụng để nội suy chính xác các kết quả Monte Carlo gần đây (para và ferro) của Ceperley và Alder vào phạm vi mật độ quan trọng cho các nguyên tử, phân tử và kim loại. Các kết quả này có thể được kết hợp với sự phụ thuộc vào spin của RPA để tạo ra một năng lượng tương quan cho một khí điện tử đồng nhất có phân cực spin với sai số tối đa được ước tính là 1 mRy và do đó có thể xác định đáng tin cậy mức độ của các hiệu chỉnh không địa phương đối với xấp xỉ mật độ spin địa phương trong các hệ thống thực. \u003C/jats:p>",{"EN":4005,"VI":4006},"Accurate spin-dependent electron liquid correlation energies for local spin density calculations: a critical analysis","Phân Tích Chính Xác Năng Lượng Tương Quan Điện Tử Phụ Thuộc Spin cho Các Tính Toán Mật Độ Spin Địa Phương: Phân Tích Phê Phán",{"VOID":4008},"10.1139/p80-159","Author affiliation is blank",[388],[390],"http://www.nrcresearchpress.com/doi/10.1139/p80-159",[4014,4023,4032],{"id":4015,"sortIndex":34,"researcher":17,"roles":4016,"affiliations":4017,"properties":4018},"2b380f0e-0125-4149-ba20-555fddb59b6e",[],[],{"openalex":4019,"title":4021},{"VOID":4020},"A5081219289",{"EN":4022},"L. Wilk",{"id":4024,"sortIndex":47,"researcher":17,"roles":4025,"affiliations":4026,"properties":4027},"eaf64e69-3ffd-4096-b7ad-6d8bb6bafa36",[],[],{"openalex":4028,"title":4030},{"VOID":4029},"A5008617550",{"EN":4031},"Marwan Nusair",{"id":4033,"sortIndex":22,"researcher":17,"roles":4034,"affiliations":4035,"properties":4036},"bd13c52d-56a5-4eb4-8ea1-98241db8b2d9",[],[],{"openalex":4037,"title":4039},{"VOID":4038},"A5067673309",{"EN":4040},"S. H. Vosko",{"url":17,"publisher":4042,"properties":4115},{"id":4043,"createTime":4044,"updateTime":4045,"relativeEntities":4046,"slug":4047,"properties":4048,"entityType":153,"verifyStatus":386,"verifyTime":17,"verifyNote":17,"syncStatus":386,"languages":17,"translateLanguages":17,"viewCount":22,"subjectFields":4059,"manageAffiliations":4060,"indexDatabases":4061,"url":4081,"thumbnailPath":17,"statistic":4082,"gsStatistic":17,"type":17,"analyzePriority":17},"80fc06e6-b551-48c7-9f9e-f99f23de8c6f","2023-05-29T11:27:44.196+00:00","2025-02-10T00:38:29.726+00:00",[],"Canadian-Journal-of-Physics",{"country":4049,"issn":4051,"introduce":4053,"eissn":4055,"title":4057},{"VOID":4050},"CA",{"VOID":4052},"00084204",{"EN":4054},"Published since 1951, this monthly journal reports significant advances in research in physics, including atomic and molecular physics; condensed matter; elementary particles and fields; nuclear physics; gases, fluid dynamics, and plasmas; electromagnetism and optics; mathematical physics; interdisciplinary, classical, and applied physics; relativity and cosmology; physics education research; statistical mechanics and thermodynamics; quantum physics and quantum computing; gravitation and string theory; biophysics; aeronomy and space physics; and astrophysics. 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